ZFIN Gene: arhgef18b

ZFIN ID: ZDB-GENE-070705-462

ZFIN ID: ZDB-GENE-070705-462

Gene Name:

rho/rac guanine nucleotide exchange factor (GEF) 18b

Gene Symbol:

arhgef18b Nomenclature History

Previous Name:

si:dkey-38o13.1

Gene Type:

protein_coding_gene

Location:

Chr: 22 Mapping Details/Browsers

Description:

Predicted to have Rho guanyl-nucleotide exchange factor activity. Involved in cilium movement. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).

Genome Resources:

Alliance (1), Gene:562264 (1), Ensembl(GRCz11):ENSDARG00000042308 (2)

GENE EXPRESSION
All Expression Data:	Fig. S3 from Choksi et al., 2014
Wild-type Stages, Structures:	Segmentation:26+ somites (22.0h-24.0h) to Segmentation:26+ somites (22.0h-24.0h)
	whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la014141Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la022131Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa10836	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa13725	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24089	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24090	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37442	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37443	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-arhgef18b	N/A	1

PHENOTYPE

Data:	2 figures from Choksi et al., 2014
Observed in:	determination of left/right symmetry Kupffer's vesicle motile cilium otolith ventricular system whole organism anterior-posterior axis

DISEASE ASSOCIATED WITH arhgef18b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Retinitis pigmentosa 78	617433

DISEASE ASSOCIATED WITH arhgef18b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cilium movement (more)
Cellular Component	cytoplasm (more)
Molecular Function	guanyl-nucleotide exchange factor activity (more)

GO Terms (all 6)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	arhgef18b-202 (1)	3618	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM arhgef18b No data available

MARKER RELATIONSHIPS

arhgef18b Contained in:

[BAC] DKEY-38O13 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005174008 (1)	4504 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX908744 (1)	122362 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A286YAR8 (1)	1038 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 11)

ORTHOLOGY for arhgef18b ( Chr: 22 )

CITATIONS (20)

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