Gene
arhgef18b
- ID
- ZDB-GENE-070705-462
- Name
- rho/rac guanine nucleotide exchange factor (GEF) 18b
- Symbol
- arhgef18b Nomenclature History
- Previous Names
-
- si:dkey-38o13.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have Rho guanyl-nucleotide exchange factor activity. Involved in cilium movement. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
- Genome Resources
- Note
- None
- All Expression Data
- from Choksi et al., 2014
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Choksi et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Retinitis pigmentosa 78 | 617433 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ARHGEF1-like, PH domain | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A286YAR8
|
1038 | |||||
|
UniProtKB:F1QCK8
|
1012 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
arhgef18b-202
(1)
|
3618 nt |
Interactions and Pathways
No data available
Plasmids
No data available