Gene
arhgef18b
- ID
- ZDB-GENE-070705-462
- Name
- rho/rac guanine nucleotide exchange factor (GEF) 18b
- Symbol
- arhgef18b Nomenclature History
- Previous Names
-
- si:dkey-38o13.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Acts upstream of or within cilium movement. Located in cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa 78. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Choksi et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Choksi et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 78 | Alliance | Retinitis pigmentosa 78 | 617433 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR037744 | ARHGEF18, PH domain |
| Domain | IPR041020 | ARHGEF1-like, PH domain |
| Family | IPR053089 | Rho guanine nucleotide exchange factor 18 |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ARHGEF18, PH domain | ARHGEF1-like, PH domain | C1-like domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Rho guanine nucleotide exchange factor 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TD86 | InterPro | 1059 | |||||||||
| UniProtKB:F1QCK8 | InterPro | 1012 | |||||||||
| UniProtKB:A0AB32TGC8 | InterPro | 1541 | |||||||||
| UniProtKB:A0AB32TGK2 | InterPro | 1526 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef18b-201
(1)
|
Ensembl | 3,224 nt | ||
| mRNA |
arhgef18b-202
(1)
|
Ensembl | 3,618 nt | ||
| mRNA |
arhgef18b-203
(1)
|
Ensembl | 3,302 nt |
Interactions and Pathways
No data available
Plasmids
No data available