ZFIN ID: ZDB-GENE-070705-462
Gene Name: rho/rac guanine nucleotide exchange factor (GEF) 18b
Gene Symbol: arhgef18b    Nomenclature History

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Previous Name: si:dkey-38o13.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Involved in cilium movement. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
Genome Resources: Alliance (1),  Gene:562264 (1),  Ensembl(GRCz11):ENSDARG00000042308 (2)
GENE EXPRESSION
All Expression Data: Fig. S3 from Choksi et al., 2014
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Segmentation:26+ somites (22.0h-24.0h)
 
DISEASE ASSOCIATED WITH arhgef18b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Retinitis pigmentosa 78 617433
DISEASE ASSOCIATED WITH arhgef18b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cilium movement (more)
Cellular Component cytoplasm (more)
Molecular Function guanyl-nucleotide exchange factor activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA arhgef18b-202 (1)    Ensembl 3618
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM arhgef18b No data available
MARKER RELATIONSHIPS
arhgef18b Contained in: [BAC] DKEY-38O13 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005174008 (1) 4504 nt
Genomic GenBank:BX908744 (1) 122362 nt
Select Tool
Polypeptide UniProtKB:A0A286YAR8 (1) 1038 aa
Sequence Information (all 11)
ORTHOLOGY for arhgef18b ( Chr: 22 )
CITATIONS (20)