Gene

matk

ID

ZDB-GENE-070705-183

Name

megakaryocyte-associated tyrosine kinase

Symbol

matk Nomenclature History

Previous Names

si:ch211-63j24.2

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Challa et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With matk Human Ortholog

No data available

Associated With matk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000980	SH2 domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001452	SH3 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR035027	CSK-like, SH2 domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	CSK-like, SH2 domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	SH2 domain	SH2 domain superfamily	SH3 domain	SH3-like domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain
UniProtKB:A0A8N7T808 InterPro	445

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	matk-201 (1) Ensembl	Havana	1324 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations