ZFIN ID: ZDB-GENE-070626-2
Gene Name: MAP/microtubule affinity-regulating kinase 1
Gene Symbol: mark1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; chemokine receptor binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chemokine-mediated signaling pathway; protein phosphorylation; and response to virus. Predicted to localize to the extracellular space. Orthologous to human MARK1 (microtubule affinity regulating kinase 1).
Genome Resources: Alliance (1),  Gene:100003170 (1),  Ensembl(GRCz11):ENSDARG00000104014 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32415 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mark1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mark1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chemokine-mediated signaling pathway (more)
    Cellular Component extracellular region (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR001772 Kinase associated domain 1 (KA1)
    Domain IPR001811 Chemokine interleukin-8-like domain
    Domain IPR015940 Ubiquitin-associated domain
    Domain IPR038717 Tc1-like transposase, DDE domain
    Family IPR030595 C-C motif chemokine 5
    Family IPR039809 Chemokine beta/gamma/delta
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR028375 KA1 domain/Ssp2, C-terminal
    Homologous_superfamily IPR036048 Chemokine interleukin-8-like superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mark1 No data available
    MARKER RELATIONSHIPS
    mark1 Encodes: [cDNA] MGC:171594 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001114476 (1) 2648 nt
    Genomic GenBank:CU638692 (1) 82280 nt
    Select Tool
    Polypeptide UniProtKB:A9JR88 (1) 772 aa
    Sequence Information (all 18)
    ORTHOLOGY for mark1 ( Chr: 22 )
    CITATIONS (14)