Gene

stx3a

ID

ZDB-GENE-070620-13

Name

syntaxin 3a

Symbol

stx3a Nomenclature History

Previous Names

zgc:165520

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in exocytosis; intracellular protein transport; and vesicle docking. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be part of SNARE complex. Predicted to be active in postsynapse; presynaptic active zone membrane; and synaptic vesicle. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stx3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Diarrhea 12, with microvillus atrophy	619445
		Retinal dystrophy and microvillus inclusion disease	619446

Associated With stx3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006012	Syntaxin/epimorphin, conserved site
Domain	IPR000727	Target SNARE coiled-coil homology domain
Domain	IPR006011	Syntaxin, N-terminal domain
Family	IPR045242	Syntaxin
Homologous_superfamily	IPR010989	SNARE

Domain Details Per Protein

Protein	Length	SNARE	Syntaxin	Syntaxin/epimorphin, conserved site	Syntaxin, N-terminal domain	Target SNARE coiled-coil homology domain
UniProtKB:B8A651 InterPro	285

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	stx3a-201 (1) Ensembl	Ensembl	1,443 nt	Select Tool ZFIN BLAST
mRNA	stx3a-202 (1) Ensembl	Ensembl	1,697 nt	Select Tool ZFIN BLAST
mRNA	stx3a-203 (1) Ensembl	Ensembl	978 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations