ZFIN ID: ZDB-GENE-070618-2
Gene Name: bone morphogenetic protein receptor, type II b (serine/threonine kinase)
Gene Symbol: bmpr2b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Exhibits transforming growth factor beta-activated receptor activity. Involved in BMP signaling pathway; circulatory system development; and notochord morphogenesis. Predicted to localize to plasma membrane and receptor complex. Is expressed in several structures, including blood island; cardiovascular system; gut; ovary; and posterior pronephric duct. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
Genome Resources: Alliance (1),  Gene:555655 (1),  Ensembl(GRCz11):ENSDARG00000020057 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026730Tg Transgenic Insertion Unknown Unknown DNA
la029534Tg Transgenic Insertion Unknown Unknown DNA
sa2507 Point Mutation Unknown Premature Stop ENU
sa5781 Point Mutation Unknown Premature Stop ENU
sa34578 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41374 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41375 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmpr2b N/A 1
    MO2-bmpr2b N/A 1
    MO3-bmpr2b N/A 4
    MO4-bmpr2b N/A 1
    DISEASE ASSOCIATED WITH bmpr2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary pulmonary hypertension Alliance Pulmonary hypertension, familial primary, 1, with or without HHT 178600
    Pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated 178600
    pulmonary venoocclusive disease Alliance Pulmonary venoocclusive disease 1 265450
    DISEASE ASSOCIATED WITH bmpr2b VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bmpr2b-201 (1)    Ensembl 4030
    ncRNA bmpr2b-002 (1)    Ensembl 591
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr2b No data available
    MARKER RELATIONSHIPS
    bmpr2b Contained in: [BAC] DKEY-56K23 (1) (order this), DKEY-230P4 (1) (order this)
    bmpr2b Encodes: [cDNA] MGC:195171 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039807 (1) 4024 nt
    Genomic GenBank:CR759883 (1) 213855 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0V0H4 (1) 1071 aa
    Sequence Information (all 14)
    ORTHOLOGY for bmpr2b ( Chr: 9 )
    CITATIONS (42)