Gene

bmpr2b

ID
ZDB-GENE-070618-2
Name
bone morphogenetic protein receptor, type II b (serine/threonine kinase)
Symbol
bmpr2b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits transforming growth factor beta-activated receptor activity. Involved in BMP signaling pathway; circulatory system development; and notochord morphogenesis. Predicted to localize to plasma membrane and receptor complex. Is expressed in several structures, including blood island; cardiovascular system; gut; ovary; and posterior pronephric duct. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmpr2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pulmonary hypertension, familial primary, 1, with or without HHT 178600
Pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated 178600
Pulmonary venoocclusive disease 1 265450
Associated With bmpr2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR045860 Snake toxin-like superfamily
Domain Details Per Protein
Protein Length Activin types I and II receptor domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Ser/Thr protein kinase, TGFB receptor Snake toxin-like superfamily
UniProtKB:Q288P2 1071
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations