ZFIN ID: ZDB-GENE-070618-1
Gene Name: bone morphogenetic protein receptor, type II a (serine/threonine kinase)
Gene Symbol: bmpr2a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits transforming growth factor beta-activated receptor activity. Involved in BMP signaling pathway; circulatory system development; and notochord morphogenesis. Predicted to localize to plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Is expressed in several structures, including blood island; ovary; pronephric duct; tail bud; and trunk vasculature. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2).
Genome Resources: Alliance (1),  Gene:562822 (1),  Ensembl(GRCz11):ENSDARG00000011941 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40652 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmpr2a N/A 1
    MO2-bmpr2a N/A 2
    MO3-bmpr2a N/A 4
    MO4-bmpr2a N/A 2
    DISEASE ASSOCIATED WITH bmpr2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary pulmonary hypertension Alliance Pulmonary hypertension, familial primary, 1, with or without HHT 178600
    Pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated 178600
    pulmonary venoocclusive disease Alliance Pulmonary venoocclusive disease 1 265450
    DISEASE ASSOCIATED WITH bmpr2a VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bmpr2a-201 (1)    Ensembl 4414
    ncRNA bmpr2a-002 (1)    Ensembl 455
    bmpr2a-003 (1)    Ensembl 488
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr2a No data available
    MARKER RELATIONSHIPS
    bmpr2a Contained in: [BAC] DKEY-211E8 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039817 (1) 3902 nt
    Genomic GenBank:BX957337 (1) 186218 nt
    Select Tool
    Polypeptide UniProtKB:F1QXI5 (1) 1003 aa
    Sequence Information (all 18)
    ORTHOLOGY for bmpr2a ( Chr: 6 )
    CITATIONS (39)