ZFIN ID: ZDB-GENE-070618-1
Gene Name: bone morphogenetic protein receptor, type II a (serine/threonine kinase)
Gene Symbol: bmpr2a
Sequence Ontology ID : SO:0000704

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Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits transforming growth factor beta-activated receptor activity; involved in several processes, including BMP signaling pathway, animal organ development, and circulatory system development;  ...
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40652 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 9 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH bmpr2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    primary pulmonary hypertension Pulmonary hypertension, familial primary, 1, with or without HHT 178600
    Pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated 178600
    pulmonary venoocclusive disease Pulmonary venoocclusive disease 1 265450
    DISEASE ASSOCIATED WITH bmpr2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transforming growth factor beta-activated receptor activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000333 (1)
  • InterPro:IPR000472 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR015770 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF01064 (1)
  • EC:2.7.11.30 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA bmpr2a-002 (1) 455
    bmpr2a-003 (1) 488
    mRNA bmpr2a-201 (1) 4414
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr2a No data available
    MARKER RELATIONSHIPS
    bmpr2aContained in: [BAC] DKEY-211E8 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039817 (1) 3902bp
    Genomic GenBank:BX957337 (1) 186218bp
    Select Tool
    Polypeptide UniProtKB:F1QXI5 (1) 1003aa
    Sequence Clusters UniGene:54062 (1)
    Sequence Information (all 19)
    OTHER bmpr2a GENE PAGES
  • Alliance (1)
  • Gene:562822 (1)
  • VEGA:OTTDARG00000027210 (1)
  • Ensembl(GRCz11):ENSDARG00000011941 (2)
  • ORTHOLOGY for bmpr2a (Chr: 6)
    CITATIONS (33)