ZFIN ID: ZDB-GENE-070615-10
Gene Name: neuregulin 2a
Gene Symbol: nrg2a    Nomenclature History

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Previous Names: nrg2, zgc:162973

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have signaling receptor binding activity. Involved in several processes, including heart trabecula morphogenesis; neural crest cell migration; and skin epidermis development. Predicted to localize to extracellular space. Is expressed in brain; epidermis; heart; median fin fold; and somite. Orthologous to human NRG2 (neuregulin 2).
Genome Resources: Alliance (1),  Gene:100006951 (1),  Ensembl(GRCz11):ENSDARG00000077818 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011165Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021943Tg Transgenic Insertion Unknown Unknown DNA
    mn0237Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23960 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nrg2a N/A 1
    DISEASE ASSOCIATED WITH nrg2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nrg2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural crest cell migration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nrg2a-201 (1)    Ensembl 2148
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nrg2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(fli1:nrg2a-2A-Tomato) fli1 2Anrg2aTomato Danio rerio 1 1
    Tg(myl7:nrg2a-2A-Tomato) myl7 2Anrg2aTomato Danio rerio 1 4
    MARKER RELATIONSHIPS
    nrg2a Contained in: [BAC] CH211-113H10 (1), DKEY-181C8 (1) (order this), DKEY-246I6 (1) (order this)
    nrg2a Encodes: [cDNA] MGC:162973 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001099254 (1) 2166 nt
    Genomic GenBank:BX511240 (1) 175187 nt
    Select Tool
    Polypeptide UniProtKB:B9VQL3 (1) 565 aa
    Sequence Information (all 41)
    ORTHOLOGY for nrg2a ( Chr: 21 )
    CITATIONS (33)