ZFIN Gene: nrg2a

ZFIN ID: ZDB-GENE-070615-10

ZFIN ID: ZDB-GENE-070615-10

Gene Name:

neuregulin 2a

Gene Symbol:

nrg2a Nomenclature History

Previous Names:

nrg2, zgc:162973

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have signaling receptor binding activity. Involved in several processes, including heart trabecula morphogenesis; neural crest cell migration; and skin epidermis development. Predicted to localize to extracellular space. Is expressed in brain; epidermis; heart; median fin fold; and somite. Orthologous to human NRG2 (neuregulin 2).

Genome Resources:

Alliance (1), Gene:100006951 (1), Ensembl(GRCz11):ENSDARG00000077818 (2)

GENE EXPRESSION
All Expression Data:	4 figures from 4 publications
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
	brain epidermis heart median fin fold somite whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la011165Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la021943Tg	Transgenic Insertion	Unknown	Unknown	DNA
mn0237Gt	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa23960	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-nrg2a	N/A	1

PHENOTYPE

Data:

8 figures from 4 publications

Observed in:

DISEASE ASSOCIATED WITH nrg2a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH nrg2a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	neural crest cell migration (more)
Cellular Component	integral component of membrane (more)
Molecular Function	signaling receptor binding (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	nrg2a-201 (1)	2148	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM nrg2a

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(fli1:nrg2a-2A-Tomato)	fli1	2A, nrg2a, Tomato	Danio rerio	1	1
Tg(myl7:nrg2a-2A-Tomato)	myl7	2A, nrg2a, Tomato	Danio rerio	1	4

MARKER RELATIONSHIPS

nrg2a Contained in:	[BAC] CH211-113H10 (1), DKEY-181C8 (1) (order this), DKEY-246I6 (1) (order this)
nrg2a Encodes:	[cDNA] MGC:162973 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001099254 (1)	2166 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX511240 (1)	175187 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B9VQL3 (1)	565 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 41)

ORTHOLOGY for nrg2a ( Chr: 21 )

CITATIONS (33)

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