Gene

casp10

ID
ZDB-GENE-070608-2
Name
caspase 10, apoptosis-related cysteine peptidase
Symbol
casp10 Nomenclature History
Previous Names
  • casp8l2
  • caspase-8b (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome (multiple); breast cancer; endocrine gland cancer (multiple); non-Hodgkin lymphoma; and primary immunodeficiency disease. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Orthologous to several human genes including CASP10 (caspase 10).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Spead et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With casp10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 2A Alliance Autoimmune lymphoproliferative syndrome, type II 603909
non-Hodgkin lymphoma Alliance Lymphoma, non-Hodgkin, somatic 605027
stomach cancer Alliance Gastric cancer, somatic 613659
Associated With casp10 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016129 Peptidase family C14A, His active site
Active_site IPR033139 Peptidase family C14A, cysteine active site
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR001875 Death effector domain
Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
Domain IPR015917 Peptidase C14A, caspase catalytic domain
Family IPR002398 Peptidase C14 family
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-like domain superfamily Death effector domain Death-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site Peptidase family C14A, His active site
UniProtKB:F1Q7E9 248
UniProtKB:A0A2U9DQS2 512
UniProtKB:A0A2R8RNP3 548
UniProtKB:F1QRT9 206
UniProtKB:E7EXV8 520
UniProtKB:Q0PKW9 188
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations