ZFIN ID: ZDB-GENE-070608-2
Gene Name: caspase 10, apoptosis-related cysteine peptidase
Gene Symbol: casp10    Nomenclature History

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Previous Names: casp8l2, caspase-8b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway and death effector domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to localize to cytoplasm. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome (multiple); breast cancer; endocrine gland cancer (multiple); non-Hodgkin lymphoma; and primary immunodeficiency disease. Orthologous to several human genes including CASP10 (caspase 10).
Genome Resources: Alliance (1),  Gene:557302 (1),  Ensembl(GRCz11):ENSDARG00000070272 (2)
GENE EXPRESSION
All Expression Data: 3 figures from Spead et al., 2018
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH casp10 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 2A Alliance Autoimmune lymphoproliferative syndrome, type II 603909
non-Hodgkin lymphoma Alliance Lymphoma, non-Hodgkin, somatic 605027
stomach cancer Alliance Gastric cancer, somatic 613659
DISEASE ASSOCIATED WITH casp10 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component cytoplasm (more)
Molecular Function cysteine-type endopeptidase activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA casp8l2-202 (1)    Ensembl 763
casp8l2-203 (1)    Ensembl 747
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM casp10 No data available
MARKER RELATIONSHIPS
casp10 Contained in: [BAC] CH73-108H4 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_680338 (1) 1869 nt
Genomic GenBank:FP102120 (1) 82853 nt
Select Tool
Polypeptide UniProtKB:A0A2R8RNP3 (1) 548 aa
Sequence Information (all 15)
ORTHOLOGY for casp10 ( Chr: 9 )
CITATIONS (20)