Gene

fadd

ID
ZDB-GENE-070606-3
Name
Fas (tnfrsf6)-associated via death domain
Symbol
fadd Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have caspase binding activity and death receptor binding activity. Involved in positive regulation of apoptotic process. Predicted to localize to CD95 death-inducing signaling complex and cytoplasm. Is expressed in several structures, including axis; brain; germ ring; immature eye; and ventral mandibular arch. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Serbanovic-Canic et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fadd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations 613759
Associated With fadd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001875 Death effector domain
Family IPR016729 FADD
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death effector domain Death-like domain superfamily FADD
UniProtKB:A0A0R4IXF0 192
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations