Gene

ngfrb

ID
ZDB-GENE-070606-2
Name
nerve growth factor receptor b
Symbol
ngfrb Nomenclature History
Previous Names
  • NGFRa (1)
  • ngfrl
  • p75 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have coreceptor activity; death receptor activity; and nerve growth factor binding activity. Involved in posterior lateral line neuromast deposition. Predicted to localize to cell surface and plasma membrane. Is expressed in cranial ganglion; posterior lateral line primordium; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ngfrb Human Ortholog
No data available
Associated With ngfrb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR034046 Tumor necrosis factor receptor 16, N-terminal
Domain IPR041448 Tumor necrosis factor receptor member 16, transmembrane domain
Family IPR022325 Tumour necrosis factor receptor 16
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily TNFR/NGFR cysteine-rich region Tumor necrosis factor receptor 16, N-terminal Tumor necrosis factor receptor member 16, transmembrane domain Tumour necrosis factor receptor 16
UniProtKB:F1R841 467
UniProtKB:Q5BJ06 392
UniProtKB:E2DGP8 431
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations