ZFIN is now using GRCz12tu for Genomic Data
Gene
itpr1b
- ID
- ZDB-GENE-070604-2
- Name
- inositol 1,4,5-trisphosphate receptor, type 1b
- Symbol
- itpr1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable inositol 1,4,5 trisphosphate binding activity and inositol 1,4,5-trisphosphate-gated calcium channel activity. Acts upstream of or within atrioventricular canal development; cranial skeletal system development; and determination of heart left/right asymmetry. Predicted to be located in endoplasmic reticulum membrane and transport vesicle membrane. Is expressed in brain. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia 15; and spinocerebellar ataxia 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Gillespie syndrome | Alliance | Gillespie syndrome | 206700 |
| spinocerebellar ataxia 15 | Alliance | Spinocerebellar ataxia 15 | 606658 |
| spinocerebellar ataxia 29 | Alliance | Spinocerebellar ataxia 29, congenital nonprogressive | 117360 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB/TL + MO1-itpr1b | standard conditions | Izarzugaza et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000699 | RIH domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013662 | RyR/IP3R Homology associated domain |
| Domain | IPR014821 | Inositol 1,4,5-trisphosphate/ryanodine receptor |
| Domain | IPR016093 | MIR motif |
| Family | IPR000493 | Inositol 1,4,5-trisphosphate receptor |
| Family | IPR015925 | Ryanodine/Inositol 1,4,5-trisphosphate receptor |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR035910 | RyR/IP3 receptor binding core, RIH domain superfamily |
| Homologous_superfamily | IPR036300 | Mir domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | Inositol 1,4,5-trisphosphate receptor | Inositol 1,4,5-trisphosphate/ryanodine receptor | Ion transport domain | Mir domain superfamily | MIR motif | RIH domain | Ryanodine/Inositol 1,4,5-trisphosphate receptor | RyR/IP3 receptor binding core, RIH domain superfamily | RyR/IP3R Homology associated domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TXG4 | InterPro | 2822 | ||||||||||
| UniProtKB:A0AB32TXI0 | InterPro | 2722 | ||||||||||
| UniProtKB:A0AB32TXI4 | InterPro | 2762 | ||||||||||
| UniProtKB:A0AB32TY48 | InterPro | 2809 | ||||||||||
| UniProtKB:A0AB32TZL3 | InterPro | 2810 | ||||||||||
| UniProtKB:A0AB32TZV0 | InterPro | 2798 | ||||||||||
| UniProtKB:A0AB32U088 | InterPro | 2807 | ||||||||||
| UniProtKB:A0AB32U0N8 | InterPro | 2797 | ||||||||||
| UniProtKB:A0AB32U0V1 | InterPro | 2812 | ||||||||||
| UniProtKB:A0AB32U0W5 | InterPro | 2759 | ||||||||||
| UniProtKB:A0AB32U276 | InterPro | 2810 | ||||||||||
| UniProtKB:A0AB32U288 | InterPro | 2719 | ||||||||||
| UniProtKB:A0AB32U2J4 | InterPro | 2790 | ||||||||||
| UniProtKB:A0AB32U2V7 | InterPro | 2782 | ||||||||||
| UniProtKB:A0AB32U3N4 | InterPro | 2787 | ||||||||||
| UniProtKB:A0AB32U3T7 | InterPro | 2800 | ||||||||||
| UniProtKB:A0AB32U3W1 | InterPro | 2767 | ||||||||||
| UniProtKB:A0AB32U4T8 | InterPro | 2783 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
itpr1b-201
(1)
|
Ensembl | 9,633 nt | ||
| mRNA |
itpr1b-202
(1)
|
Ensembl | 8,196 nt | ||
| mRNA |
itpr1b-203
(1)
|
Ensembl | 7,746 nt | ||
| mRNA |
itpr1b-204
(1)
|
Ensembl | 1,788 nt | ||
| mRNA |
itpr1b-205
(1)
|
Ensembl | 7,602 nt | ||
| mRNA |
itpr1b-206
(1)
|
Ensembl | 8,154 nt | ||
| mRNA |
itpr1b-207
(1)
|
Ensembl | 8,223 nt | ||
| mRNA |
itpr1b-208
(1)
|
Ensembl | 7,917 nt | ||
| mRNA |
itpr1b-209
(1)
|
Ensembl | 8,148 nt | ||
| mRNA |
itpr1b-210
(1)
|
Ensembl | 7,731 nt | ||
| mRNA |
itpr1b-211
(1)
|
Ensembl | 7,743 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance