ZFIN ID: ZDB-GENE-070604-2
Gene Name: inositol 1,4,5-trisphosphate receptor, type 1b
Gene Symbol: itpr1b    Nomenclature History

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Previous Names: ITPR1b2 (1), ITPRx (1), zmp:0000000743

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have inositol 1,4,5 trisphosphate binding activity and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to localize to endoplasmic reticulum and integral component of membrane. Is expressed in Purkinje cell; cerebellum; granule cell; hindbrain; and optic tectum. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1).
Genome Resources: Alliance (1),  Gene:100149388 (1),  Ensembl(GRCz11):ENSDARG00000074149 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH itpr1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Gillespie syndrome Alliance Gillespie syndrome 206700
spinocerebellar ataxia type 15 Alliance Spinocerebellar ataxia 15 606658
spinocerebellar ataxia type 29 Alliance Spinocerebellar ataxia 29, congenital nonprogressive 117360
DISEASE ASSOCIATED WITH itpr1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process calcium ion transmembrane transport (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function calcium channel activity (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA itpr1b-201 (1)    Ensembl 9633
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM itpr1b No data available
MARKER RELATIONSHIPS
itpr1b Contained in: [BAC] DKEYP-81F11, DKEYP-87F2 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_021479879 (1)
Genomic GenBank:BX914197 (1) 198600 nt
Select Tool
Polypeptide UniProtKB:E7FB06 (1) 2782 aa
Sequence Information (all 19)
ORTHOLOGY for itpr1b ( Chr: 11 )
CITATIONS (20)