ZFIN ID: ZDB-GENE-070604-1
Gene Name: Rho guanine nucleotide exchange factor (GEF) 11
Gene Symbol: arhgef11    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including epithelial cilium movement involved in extracellular fluid movement; otolith development; and stress fiber assembly. Predicted to localize to cytoplasm. Is expressed in central nervous system; head; and pronephric duct. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11).
Genome Resources: Alliance (1),  Gene:565268 (1),  Ensembl(GRCz11):ENSDARG00000052482 (2)
GENE EXPRESSION
All Expression Data: 3 figures from Panizzi et al., 2007
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15205 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20855 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26876 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-arhgef11 N/A 1
    MO2-arhgef11 N/A 1
    DISEASE ASSOCIATED WITH arhgef11 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH arhgef11 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process stress fiber assembly (more)
    Cellular Component cytoplasm (more)
    Molecular Function G-protein alpha-subunit binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef11-201 (1)    Ensembl 2252
    arhgef11-202 (1)    Ensembl 521
    arhgef11-203 (1)    Ensembl 5755
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef11 No data available
    MARKER RELATIONSHIPS
    arhgef11 Contained in: [BAC] DKEYP-67A8 (1)
    arhgef11 Encodes: [cDNA] MGC:195123 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001031840 (1) 4254 nt
    Genomic GenBank:BX323566 (1) 108226 nt
    Select Tool
    Polypeptide UniProtKB:B3DJQ2 (1) 1417 aa
    Sequence Information (all 19)
    ORTHOLOGY for arhgef11 ( Chr: 7 )
    CITATIONS (25)