Gene
arhgef11
- ID
- ZDB-GENE-070604-1
- Name
- Rho guanine nucleotide exchange factor (GEF) 11
- Symbol
- arhgef11 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including epithelial cilium movement involved in extracellular fluid movement; otolith development; and stress fiber assembly. Predicted to localize to cytoplasm and membrane. Is expressed in central nervous system; head; and pronephric duct. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Panizzi et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Panizzi et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR015212 | Regulator of G protein signalling-like domain |
| Domain | IPR037889 | Rho guanine nucleotide exchange factor 11, RGS domain |
| Domain | IPR041020 | ARHGEF1-like, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036305 | RGS domain superfamily |
| Homologous_superfamily | IPR044926 | RGS, subdomain 2 |
Domain Details Per Protein
| Protein | Length | ARHGEF1-like, PH domain | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Regulator of G protein signalling-like domain | RGS domain superfamily | RGS, subdomain 2 | Rho guanine nucleotide exchange factor 11, RGS domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q49U75
|
1417 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef11-201
(1)
|
Ensembl | 2,252 nt | ||
| mRNA |
arhgef11-202
(1)
|
Ensembl | 521 nt | ||
| mRNA |
arhgef11-203
(1)
|
Ensembl | 5,755 nt |
Interactions and Pathways
No data available
Plasmids
No data available