ZFIN ID: ZDB-GENE-070531-1
Gene Name: Bruton agammaglobulinemia tyrosine kinase
Gene Symbol: btk
Location: Chr: 14   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. S2 from James et al., 2009
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Hatching:Long-pec (48.0h-60.0h)
  hematopoietic system, whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
sa13221 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15417 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-btk (1), MO2-btk (1)
    PHENOTYPE
    Data: Fig. 4 from James et al., 2009
    Observed in: eye, whole organism anterior region, whole organism
    DISEASE ASSOCIATED WITH btk HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Bruton-type agammaglobulinemia Agammaglobulinemia, X-linked 1 300755
    Agammaglobulinemia and isolated hormone deficiency 307200
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component extrinsic component of cytoplasmic side of plasma membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR001562 (1)
  • InterPro:IPR001849 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50002 (1)
  • PROSITE:PS50003 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS51113 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF00018 (1)
  • Pfam:PF00169 (1)
  • Pfam:PF00779 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA btk-001 (1) 2782
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM btk No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    btk Contained in: [BAC] CH211-127L12 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009291222 (1) 2716 bp
    Genomic GenBank:BX005218 (1) 183670 bp
    Select Tool
    Polypeptide UniProtKB:E7F4S0 (1) 660 aa
    Sequence Clusters UniGene:83181 (1)
    Sequence Information (all 10)
    OTHER btk GENE PAGES
  • Gene:568653 (1)
  • VEGA:OTTDARG00000034082 (1)
  • Ensembl(Zv9):ENSDARG00000004433 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish btk 14  
    Human BTK X (Xq21.33-q22)
  • OMIM:300300
  • Gene:695
  • Orthology Details
    CITATIONS (13)