ZFIN ID: ZDB-GENE-070531-1
Gene Name: Bruton agammaglobulinemia tyrosine kinase
Gene Symbol: btk
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. S2 from James et al., 2009
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Hatching:Long-pec (48.0h-60.0h)
  hematopoietic system, whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13221 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15417 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-btk (1), MO2-btk (1)
    PHENOTYPE
    Data: Fig. 4 from James et al., 2009
    Observed in: eye, whole organism anterior region, whole organism
    DISEASE ASSOCIATED WITH btk HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Bruton-type agammaglobulinemia Agammaglobulinemia, X-linked 1 300755
    Agammaglobulinemia and isolated hormone deficiency 307200
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component extrinsic component of cytoplasmic side of plasma membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR001562 (1)
  • InterPro:IPR001849 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50002 (1)
  • PROSITE:PS50003 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS51113 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF00018 (1)
  • Pfam:PF00169 (1)
  • Pfam:PF00779 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA btk-001 (1) 2634
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM btk No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    btkContained in: [BAC] CH211-127L12 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_691995 (1) 2706bp
    Genomic GenBank:BX005218 (1) 183670bp
    Select Tool
    Polypeptide UniProtKB:F8W3B7 (1) 640aa
    Sequence Clusters UniGene:83181 (1)
    Sequence Information (all 7)
    OTHER btk GENE PAGES
  • Gene:568653 (1)
  • VEGA:OTTDARG00000034082 (1)
  • Ensembl(GRCz10):ENSDARG00000004433 (1)
  • ORTHOLOGY for btk (Chr: 14)
    Species Symbol Chromosome Accession # Evidence
    Human BTK X
  • Gene:695
  • OMIM:300300
  • HGNC:1133
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (13)