ZFIN ID: ZDB-GENE-070531-1
Gene Name: Bruton agammaglobulinemia tyrosine kinase
Gene Symbol: btk
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. S2 from James et al., 2009
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Hatching:Long-pec (48.0h-60.0h)
  hematopoietic system, whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13221 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15417 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-btk (1), MO2-btk (1)
    PHENOTYPE
    Data: Fig. 4 from James et al., 2009
    Observed in: eye, whole organism anterior region, whole organism
    DISEASE ASSOCIATED WITH btk HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Bruton-type agammaglobulinemia Agammaglobulinemia, X-linked 1 300755
    isolated growth hormone deficiency type III Agammaglobulinemia and isolated hormone deficiency 307200
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component extrinsic component of cytoplasmic side of plasma membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719
  • InterPro:IPR000980
  • InterPro:IPR001245
  • InterPro:IPR001452
  • InterPro:IPR001562
  • InterPro:IPR001849
  • InterPro:IPR008266
  • InterPro:IPR011009
  • InterPro:IPR011993
  • InterPro:IPR017441
  • InterPro:IPR020635
  • PROSITE:PS00107
  • PROSITE:PS00109
  • PROSITE:PS50001
  • PROSITE:PS50002
  • PROSITE:PS50003
  • PROSITE:PS50011
  • PROSITE:PS51113
  • Pfam:PF00017
  • Pfam:PF00018
  • Pfam:PF00169
  • Pfam:PF00779
  • Pfam:PF07714
  • EC:2.7.10.2
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA btk-001 (1) 2634
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM btk No data available
    MARKER RELATIONSHIPS
    btkContained in: [BAC] CH211-127L12 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_691995 (1) 2598bp
    Genomic GenBank:BX005218 (1) 183670bp
    Select Tool
    Polypeptide UniProtKB:F8W3B7 640aa
    Sequence Clusters UniGene:83181 (1)
    Sequence Information (all 12)
    OTHER btk GENE PAGES
  • Gene:568653 (1)
  • VEGA:OTTDARG00000034082 (1)
  • Ensembl(GRCz10):ENSDARG00000004433 (1)
  • ORTHOLOGY for btk (Chr: 14)
    CITATIONS (11)