ZFIN ID: ZDB-GENE-070522-3
Gene Name: glucosidase, beta (bile acid) 2
Gene Symbol: gba2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits beta-glucosidase activity. Involved in axonogenesis and central nervous system development. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2).
Genome Resources: Alliance (1),  Gene:559240 (1),  Ensembl(GRCz11):ENSDARG00000061472 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15747 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gba2 N/A 1
    DISEASE ASSOCIATED WITH gba2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 46 Alliance Spastic paraplegia 46, autosomal recessive 614409
    DISEASE ASSOCIATED WITH gba2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component plasma membrane (more)
    Molecular Function beta-glucosidase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gba2-202 (1)    Ensembl 3595
    gba2-203 (1)    Ensembl 507
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gba2 No data available
    MARKER RELATIONSHIPS
    gba2 Contained in: [BAC] CH211-69E13
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005172332 (1) 3872 nt
    Genomic GenBank:BX510349 (1) 152064 nt
    Select Tool
    Polypeptide UniProtKB:E7F5W0 (1) 851 aa
    Sequence Information (all 7)
    ORTHOLOGY for gba2 ( Chr: 7 )
    CITATIONS (22)