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General Information
ZIRC
ZFIN ID: ZDB-GENE-070521-8
Gene Name: apelin
Gene Symbol: apln    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have apelin receptor binding activity. Involved in ameboidal-type cell migration; circulatory system development; and response to hypoxia. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in congestive heart failure. Is expressed in several structures, including axial chorda mesoderm; axis; cardiovascular system; notochord; and somite. Orthologous to human APLN (apelin).
Genome Resources: Alliance (1),  Gene:798375 (1),  Ensembl(GRCz11):ENSDARG00000053279 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mu267 Indel Exon 1 Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPP4-apln
1
CRISPR1-apln 2
CRISPR2-apln
1
CRISPR3-apln
1
MO1-apln N/A 4
MO2-apln N/A 1
MO3-apln N/A 4
MO4-apln N/A 1
DISEASE ASSOCIATED WITH apln HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH apln VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell migration involved in gastrulation (more)
Cellular Component extracellular region (more)
Molecular Function apelin receptor binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR026155 (1)
  • Pfam:PF15360 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apln-201 (1)    Ensembl 4435
    apln-202 (1)    Ensembl 846
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apln No data available
    MARKER RELATIONSHIPS
    apln Contained in: [BAC] DKEY-61O11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001166124 (1) 3250 bp
    Genomic GenBank:AL929104 (1) 187365 bp
    Select Tool
    Polypeptide UniProtKB:Q4TTN8 (1) 77 aa
    Sequence Clusters UniGene:30822 (1)
    Sequence Information (all 11)
    ORTHOLOGY for apln ( Chr: 14 )
    CITATIONS (39)