ZFIN ID: ZDB-GENE-070509-1
Gene Name: growth hormone receptor a
Gene Symbol: ghra
Sequence Ontology ID : SO:0000704

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Previous Names: ghr, zgc:162141

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have several functions, including cytokine binding activity, growth factor binding activity, and growth hormone receptor activity; predicted to be involved in growth hormone receptor  ...
GENE EXPRESSION
All Expression Data: 9 figures from 8 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34437 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa34438 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ghra HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    familial hypercholesterolemia {Hypercholesterolemia, familial, modifier of} 143890
    Laron syndrome Laron dwarfism 262500
    Increased responsiveness to growth hormone 604271
    Growth hormone insensitivity, partial 604271
    DISEASE ASSOCIATED WITH ghra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine receptor activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003528 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR015152 (1)
  • InterPro:IPR025871 (1)
  • InterPro:IPR036116 (1)
  • PROSITE:PS01352 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF09067 (1)
  • Pfam:PF12772 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ghra-001 (1) 2359
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ghra
    MARKER RELATIONSHIPS
    ghraContained in: [BAC] CH211-194C22 (order this), CH211-226F24 (order this), DKEY-46A10 (1) (order this)
    ghraEncodes: [cDNA] MGC:162141 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083578 (1) 2269bp
    Genomic GenBank:CR352327 203325bp Blast at MegaBLAST
    Polypeptide UniProtKB:A4IG30 (1) 570aa
    Sequence Clusters UniGene:88472 (1)
    Sequence Information (all 28)
    OTHER ghra GENE PAGES
  • Alliance (1)
  • Gene:100001424 (1)
  • VEGA:OTTDARG00000026836 (1)
  • ORTHOLOGY for ghra (Chr: 8)
    CITATIONS (52)