ZFIN ID: ZDB-GENE-070508-3
Gene Name: dopamine receptor D4b
Gene Symbol: drd4b    Nomenclature History

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Previous Name: drd4c (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to localize to dendrite and integral component of plasma membrane. Is expressed in endoderm; nervous system; neural tube; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4).
Genome Resources: Alliance (1),  Gene:503565 (1),  Ensembl(GRCz11):ENSDARG00000035820 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2373 Point Mutation Unknown Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH drd4b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
attention deficit hyperactivity disorder Alliance {Attention deficit-hyperactivity disorder} 143465
Autonomic nervous system dysfunction
DISEASE ASSOCIATED WITH drd4b VIA EXPERIMENTAL MODELS No data available
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA drd4b-201 (1)    Ensembl 1177
drd4b-202 (1)    Ensembl 493
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM drd4b No data available
MARKER RELATIONSHIPS
drd4b Contained in: [BAC] CH211-222K9 (1)
drd4b Encodes: [cDNA] MGC:194401 (1), MGC:194427 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001012618 (1) 1177 nt
Genomic GenBank:BX663604 (1) 161194 nt
Select Tool
Polypeptide UniProtKB:Q5DJ14 (1) 382 aa
Sequence Information (all 16)
ORTHOLOGY for drd4b ( Chr: 7 )
CITATIONS (28)