Gene

drd4b

ID
ZDB-GENE-070508-3
Name
dopamine receptor D4b
Symbol
drd4b Nomenclature History
Previous Names
  • drd4c (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to localize to dendrite and integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Is expressed in endoderm; nervous system; neural tube; and pharyngeal arch 3-7 skeleton. Orthologous to human DRD4 (dopamine receptor D4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With drd4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
attention deficit hyperactivity disorder Alliance {Attention deficit-hyperactivity disorder} 143465
Autonomic nervous system dysfunction
Associated With drd4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000929 Dopamine receptor family
Family IPR002185 Dopamine D4 receptor
Domain Details Per Protein
Protein Length Dopamine D4 receptor Dopamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q5DJ14 382
UniProtKB:B0S7D2 135
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations