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ZIRC
ZFIN ID: ZDB-GENE-070424-30
Gene Name: cyclin D2, a
Gene Symbol: ccnd2a    Nomenclature History

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Previous Names: ccnd2, gb:bi671621, zgc:162280

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to contribute to protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to the cyclin-dependent protein kinase holoenzyme complex; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; invasive lobular carcinoma; prostate cancer; and transitional cell carcinoma. Is expressed in pharyngeal arch and testis. Orthologous to human CCND2 (cyclin D2).
Genome Resources: Alliance (1),  Gene:799608 (1),  Ensembl(GRCz11):ENSDARG00000051748 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014671Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023170Tg Transgenic Insertion Unknown Unknown DNA
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ccnd2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 615938
    DISEASE ASSOCIATED WITH ccnd2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic cell cycle phase transition (more)
    Cellular Component nucleus (more)
    Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ccnd2a-201 (1)    Ensembl 1293
    ccnd2a-203 (1)    Ensembl 287
    ccnd2a-204 (1)    Ensembl 476
    ccnd2a-205 (1)    Ensembl 727
    ncRNA ccnd2a-002 (1) 414
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ccnd2a No data available
    MARKER RELATIONSHIPS
    ccnd2a Contained in: [BAC] CH211-254A7 (1) (order this), DKEY-15A12 (1) (order this), DKEY-217G8 (1) (order this)
    ccnd2a Encodes: [cDNA] MGC:162280 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001089445 (1) 1312 bp
    Genomic GenBank:CU468035 (1) 225398 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A3KNN7 (1) 298 aa
    Sequence Clusters UniGene:159818 (1)
    Sequence Information (all 23)
    ORTHOLOGY for ccnd2a ( Chr: 25 )
    CITATIONS (32)