Gene

grin2ab

ID
ZDB-GENE-070424-223
Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
Symbol
grin2ab Nomenclature History
Previous Names
  • NR2A.1 (1)
  • im:7137621
  • si:dkey-20i6.1
  • zNMDA-2A.1 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Is expressed in retina and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. S4 from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grin2ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Landau-Kleffner syndrome Alliance Epilepsy, focal, with speech disorder and with or without mental retardation 245570
Associated With grin2ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001320 Ionotropic glutamate receptor
Domain IPR001828 Receptor, ligand binding region
Domain IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
Domain IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family IPR001508 Ionotropic glutamate receptor, metazoa
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Glutamate [NMDA] receptor, epsilon subunit, C-terminal Ionotropic glutamate receptor Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Ionotropic glutamate receptor, metazoa Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:F1QDE5 1445
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations