ZFIN ID: ZDB-GENE-070424-223
Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
Gene Symbol: grin2ab    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: NR2A.1 (1), im:7137621, si:dkey-20i6.1, zNMDA-2A.1 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Is expressed in retina and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A).
Genome Resources: Alliance (1),  Gene:570493 (1),  Ensembl(GRCz11):ENSDARG00000070543 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 3 figures (4 images) from Thisse et al., 2004 [IMAGE:7137621]
Wild-type Stages, Structures: Pharyngula:High-pec (42.0h-48.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a279 Small Deletion Unknown Unknown CRISPR
la021354Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1696 Point Mutation Unknown Premature Stop ENU
    sa19422 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39547 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko169b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grin2ab 1
    CRISPR2-grin2ab 1
    CRISPR3-grin2ab 1
    CRISPR4-grin2ab 1
    CRISPR5-grin2ab 1
    DISEASE ASSOCIATED WITH grin2ab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Landau-Kleffner syndrome Alliance Epilepsy, focal, with speech disorder and with or without mental retardation 245570
    DISEASE ASSOCIATED WITH grin2ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component cell junction (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grin2ab-202 (1)    Ensembl 5416
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grin2ab No data available
    MARKER RELATIONSHIPS
    grin2ab Contained in: [BAC] CH73-49M18 (1), DKEY-20I6 (1) (order this), DKEY-190M16 (order this), DKEYP-10H11
    grin2ab Encodes: [EST] IMAGE:7137621 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009306215 (1)
    Genomic GenBank:BX649405 231915 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QDE5 (1) 1445 aa
    Sequence Information (all 15)
    ORTHOLOGY for grin2ab ( Chr: 1 )
    CITATIONS (31)