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ZIRC
ZFIN ID: ZDB-GENE-070424-1
Gene Name: kit ligand a
Gene Symbol: kitlga    Nomenclature History

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Previous Names: kitla (1), slk (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have cytokine activity and stem cell factor receptor binding activity. Involved in melanocyte differentiation. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69. Is expressed in several structures, including endocrine system; gut; integument; neural crest cell; and segmental plate. Orthologous to human KITLG (KIT ligand).
Genome Resources: Alliance (1),  Gene:553179 (1),  Ensembl(GRCz11):ENSDARG00000070917 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24647 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44268 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc244b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kitlga N/A 2
    DISEASE ASSOCIATED WITH kitlga HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 69 Alliance Deafness, autosomal dominant 69, unilateral or asymmetric 616697
    familial progressive hyperpigmentation with or without hypopigmentation Alliance Hyperpigmentation with or without hypopigmentation 145250
    [Skin/hair/eye pigmentation 7, blond/brown hair] 611664
    DISEASE ASSOCIATED WITH kitlga VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process melanocyte differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function stem cell factor receptor binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003452 (1)
  • InterPro:IPR009079 (1)
  • Pfam:PF02404 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kitlga-201 (1)    Ensembl 1613
    kitlga-202 (1)    Ensembl 801
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kitlga
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(CMV:kitlga-JRed) JRedkitlga Danio rerio 1 2
    Tg(hsp70l:kitlga) hsp70l kitlga Danio rerio 1 5
    Tg(hsp70l:kitlga,csf1a,NLS-CFP) hsp70l csf1akitlga Danio rerio 1 2
    Tg(hsp70l:kitlga,csf1b,NLS-CFP) hsp70l CFPcsf1bkitlga Danio rerio 1 2
    MARKER RELATIONSHIPS
    kitlga Contained in: [BAC] DKEY-30I6 (1) (order this), DKEY-106N21 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001018123 (1)
    Genomic GenBank:BX901919 (1) 233401 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q56JH6 (1) 272 aa
    Sequence Clusters UniGene:84231 (1)
    Sequence Information (all 12)
    ORTHOLOGY for kitlga ( Chr: 25 )
    CITATIONS (43)