Gene

kitlga

ID

ZDB-GENE-070424-1

Name

kit ligand a

Symbol

kitlga Nomenclature History

Previous Names

kitla (1)
slk (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within melanocyte differentiation. Predicted to be located in several cellular components, including extracellular region; filopodium; and lamellipodium. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; endocrine system; muscle; neural crest cell; and segmental plate. Human ortholog(s) of this gene implicated in Waardenburg syndrome; autosomal dominant nonsyndromic deafness 69; familial progressive hyperpigmentation with or without hypopigmentation; and pigmentation disease. Orthologous to human KITLG (KIT ligand).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kitlga Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 69	Alliance	Deafness, autosomal dominant 69, unilateral or asymmetric	616697
familial progressive hyperpigmentation with or without hypopigmentation	Alliance	Hyperpigmentation with or without hypopigmentation	145250
		Waardenburg syndrome, type 2F	619947
		[Skin/hair/eye pigmentation 7, blond/brown hair]	611664

Associated With kitlga Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR003452	Stem cell factor
Homologous_superfamily	IPR009079	Four-helical cytokine-like, core

Domain Details Per Protein

Protein	Additional Resources	Length	Four-helical cytokine-like, core	Stem cell factor
UniProtKB:Q56JH6	InterPro	272

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kitlga-201 (1) Ensembl	Ensembl	1,613 nt	Select Tool ZFIN BLAST
mRNA	kitlga-202 (1) Ensembl	Ensembl	801 nt	Select Tool ZFIN BLAST
mRNA	kitlga-203 (1) Ensembl	Ensembl	819 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations