ZFIN ID: ZDB-GENE-070423-1
Gene Name: glutamine--fructose-6-phosphate transaminase 1
Gene Symbol: gfpt1    Nomenclature History

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Previous Names: eartha (1), harvest moon (1), hmn (1), unm_z110

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in several processes, including melanocyte differentiation; neuromuscular junction development; and skeletal system development. Is expressed in notochord and polster. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12 and obesity. Orthologous to human GFPT1 (glutamine--fructose-6-phosphate transaminase 1).
Genome Resources: Alliance (1),  Gene:567861 (1),  Ensembl(GRCz11):ENSDARG00000057465 (2),  Ensembl(GRCz11):ENSDARG00000086866 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
j23e1 Point Mutation Exon 3 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21389 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34504 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • z110 Point Mutation Exon 11 Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gfpt1 N/A 2
    MO2-gfpt1 N/A 2
    DISEASE ASSOCIATED WITH gfpt1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 12 Alliance Myasthenia, congenital, 12, with tubular aggregates 610542
    DISEASE ASSOCIATED WITH gfpt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chondrocyte development (more)
    Molecular Function carbohydrate derivative binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gfpt1-202 (1)    Ensembl 377
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gfpt1 No data available
    MARKER RELATIONSHIPS
    gfpt1 Contained in: [Fosmid] ZFOS-1058E7 (1)
    gfpt1 Encodes: [cDNA] MGC:194557 (1), MGC:194569 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034981 (1) 2079 nt
    Genomic GenBank:CU929036 (1) 35076 nt
    Select Tool
    Polypeptide UniProtKB:Q3S344 (1) 682 aa
    Sequence Information (all 21)
    ORTHOLOGY for gfpt1 ( Chr: 8 )
    CITATIONS (27)