ZFIN ID: ZDB-GENE-070410-96
Gene Name: fukutin
Gene Symbol: fktn    Nomenclature History

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Previous Names: fcmd (1), im:7163166 (1), zgc:162828

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in muscle fiber development; regulation of protein glycosylation; and vasculogenesis. Is expressed in several structures, including brain; cloacal chamber; fin bud; myotome; and shield. Human ortholog(s) of this gene implicated in dilated cardiomyopathy (multiple) and muscular dystrophy (multiple). Orthologous to human FKTN (fukutin).
Genome Resources: Alliance (1),  Gene:100006345 (1),  Ensembl(GRCz11):ENSDARG00000059437 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-fktn N/A 2
MO2-fktn N/A 1
DISEASE ASSOCIATED WITH fktn HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2M Alliance Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 4 611588
dilated cardiomyopathy 1X Alliance Cardiomyopathy, dilated, 1X 611615
Fukuyama congenital muscular dystrophy Alliance Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 253800
muscular dystrophy-dystroglycanopathy Alliance Muscular dystrophy-dystroglycanopathy (congenital without mental retardation), type B, 4 613152
DISEASE ASSOCIATED WITH fktn VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of protein glycosylation (more)
Molecular Function molecular_function (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA fktn-201 (1)    Ensembl 2367
ncRNA fktn-002 (1)    Ensembl 503
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM fktn No data available
MARKER RELATIONSHIPS
fktn Contained in: [BAC] CH211-286A10, DKEY-204E18 (1) (order this)
fktn Encodes: [EST] IMAGE:7163166 (1)
[cDNA] MGC:162828 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001042694 (1)
Genomic GenBank:BX072578 183498 nt
Select Tool
Polypeptide UniProtKB:A3KP10 (1) 457 aa
Sequence Information (all 17)
ORTHOLOGY for fktn ( Chr: 5 )
CITATIONS (22)