Gene

srebf2

ID
ZDB-GENE-070410-8
Name
sterol regulatory element binding transcription factor 2
Symbol
srebf2 Nomenclature History
Previous Names
  • zgc:158371
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of Notch signaling pathway. Acts upstream of or within liver development. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus. Is expressed in liver and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With srebf2 Human Ortholog
No data available
Associated With srebf2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:F1RC21 1095
UniProtKB:A3KNA7 1099
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations