ZFIN ID: ZDB-GENE-070410-32
Gene Name: adrenoceptor beta 2, surface b
Gene Symbol: adrb2b    Nomenclature History

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Previous Name: zgc:162188

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have beta2-adrenergic receptor activity; epinephrine binding activity; and norepinephrine binding activity. Involved in regulation of heart rate. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including digestive system; eye; heart; kidney; and musculature system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2).
Genome Resources: Alliance (1),  Gene:100037315 (1),  Ensembl(GRCz11):ENSDARG00000054510 (1)
GENE EXPRESSION
All Expression Data: 10 figures from 5 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6680 Point Mutation Unknown Premature Stop ENU
sa37355 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-adrb2b N/A 1
    MO2-adrb2b N/A 2
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH adrb2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    asthma Alliance {Asthma, nocturnal, susceptibility to} 600807
    obesity Alliance {Obesity, susceptibility to} 601665
    Beta-2-adrenoreceptor agonist, reduced response to
    DISEASE ASSOCIATED WITH adrb2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of heart rate (more)
    Cellular Component integral component of membrane (more)
    Molecular Function adrenergic receptor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adrb2b-201 (1)    Ensembl 3764
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adrb2b No data available
    MARKER RELATIONSHIPS
    adrb2b Contained in: [BAC] DKEY-212J2 (1) (order this)
    adrb2b Encodes: [cDNA] MGC:162188 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089471 (1) 3728 nt
    Genomic GenBank:CR762496 (1) 239780 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QNL3 (1) 409 aa
    Sequence Information (all 15)
    ORTHOLOGY for adrb2b ( Chr: 21 )
    CITATIONS (30)