ZFIN ID: ZDB-GENE-070410-22
Gene Name: mitochondrial calcium uptake 1
Gene Symbol: micu1    Nomenclature History

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Previous Name: zgc:162148 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to be involved in calcium ion import; mitochondrial calcium ion transmembrane transport; and positive regulation of mitochondrial calcium ion concentration. Predicted to localize to integral component of mitochondrial membrane; mitochondrial intermembrane space; and uniplex complex. Is expressed in female organism; heart; and heart tube. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1).
Genome Resources: Alliance (1),  Gene:561210 (1),  Ensembl(GRCz11):ENSDARG00000063358 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027463Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31903 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42129 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42130 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-micu1 N/A 1
    TALEN1-micu1
    1
    PHENOTYPE
    Data: Fig. 3 from Soman et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH micu1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    myopathy with extrapyramidal signs Alliance Myopathy with extrapyramidal signs 615673
    DISEASE ASSOCIATED WITH micu1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion import (more)
    Cellular Component integral component of mitochondrial membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA micu1-202 (1)    Ensembl 2848
    micu1-203 (1)    Ensembl 604
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM micu1 No data available
    MARKER RELATIONSHIPS
    micu1 Contained in: [BAC] CH211-199I24 (1), DKEYP-24H9 (1)
    micu1 Encodes: [cDNA] MGC:162148 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083833 (1) 2772 nt
    Genomic GenBank:CT025754 (1) 106478 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q9T2 (1) 493 aa
    Sequence Information (all 23)
    ORTHOLOGY for micu1 ( Chr: 13 )
    CITATIONS (26)