| ZFIN ID: ZDB-GENE-070410-22 |
| Gene Name: | mitochondrial calcium uptake 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | micu1 Nomenclature History |
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Attributions
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| Previous Name: | zgc:162148 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 13 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have calcium ion binding activity. Predicted to be involved in calcium ion import; mitochondrial calcium ion transmembrane transport; and positive regulation of mitochondrial calcium ion concentration. Predicted to localize to integral component of mitochondrial membrane; mitochondrial intermembrane space; and uniplex complex. Is expressed in female organism; heart; and heart tube. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:561210 (1), Ensembl(GRCz11):ENSDARG00000063358 (2) | |||||||||||||
| All Expression Data: | 3 figures from 3 publications |
| Wild-type Stages, Structures: | Pharyngula:Prim-25 (36.0h-42.0h) to Adult (90d-730d, breeding adult) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| la027463Tg | Transgenic Insertion | Unknown | Unknown | DNA |
|
| sa31903 | Point Mutation | Unknown | Premature Stop | ENU |
|
| sa42129 | Point Mutation | Unknown | Splice Site | ENU |
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| sa42130 | Point Mutation | Unknown | Splice Site | ENU |
|
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| MO1-micu1 | N/A | 1 |
| TALEN1-micu1 |
|
1 |
PHENOTYPE
| Data: | Fig. 3 from Soman et al., 2017 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myopathy with extrapyramidal signs | Alliance | Myopathy with extrapyramidal signs | 615673 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | calcium ion import (more) |
| Cellular Component | integral component of mitochondrial membrane (more) |
| Molecular Function | calcium ion binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
micu1-202
(1)
|
2848 |
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|
|
micu1-203
(1)
|
604 |
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|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
CONSTRUCTS WITH SEQUENCES FROM micu1
No data available
MARKER RELATIONSHIPS
| micu1 Contained in: | [BAC] CH211-199I24 (1), DKEYP-24H9 (1) |
| micu1 Encodes: | [cDNA] MGC:162148 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001083833 (1) | 2772 nt |
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| Genomic | GenBank:CT025754 (1) | 106478 nt | |
| Polypeptide | UniProtKB:A0A2R8Q9T2 (1) | 493 aa |
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ORTHOLOGY for micu1 (
Chr:
13
)
CITATIONS (26)