ZFIN ID: ZDB-GENE-070410-133
Gene Name: tumor necrosis factor receptor superfamily, member 1B
Gene Symbol: tnfrsf1b    Nomenclature History

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Previous Names: RANK (1), tnfr2 (1), zgc:163064

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Involved in several processes, including peripheral nervous system axon ensheathment; positive regulation of hematopoietic progenitor cell differentiation; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including Legionnaires' disease; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Is expressed in several structures, including head; head mesenchyme; hematopoietic system; osteoclast; and scale. Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B).
Genome Resources: Alliance (1),  Gene:100037357 (1),  Ensembl(GRCz11):ENSDARG00000070165 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tnfrsf1b
1
CRISPR2-tnfrsf1b
1
CRISPR3-tnfrsf1b
1
CRISPR4-tnfrsf1b
1
MO1-tnfrsf1b N/A 1
MO2-tnfrsf1b N/A 5
MO3-tnfrsf1b N/A 1
MO4-tnfrsf1b N/A 2
DISEASE ASSOCIATED WITH tnfrsf1b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tnfrsf1b VIA EXPERIMENTAL MODELS No data available
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tnfrsf1b-201 (1)    Ensembl 3935
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tnfrsf1b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(4xUAS:tnfrsf1b,myl7:EGFP) myl7UAS EGFPtnfrsf1b Danio rerio 1 3
MARKER RELATIONSHIPS
tnfrsf1b Contained in: [BAC] DKEY-207B20 (order this), DKEYP-61B2
tnfrsf1b Encodes: [cDNA] MGC:163064 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001089510 (1) 1612 nt
Genomic GenBank:CR848022 (1) 141504 nt
Select Tool
Polypeptide UniProtKB:F1RAS9 (1) 425 aa
Sequence Information (all 18)
ORTHOLOGY for tnfrsf1b ( Chr: 11 )
CITATIONS (40)