ZFIN ID: ZDB-GENE-070402-2
Gene Name: amyotrophic lateral sclerosis 2a (juvenile)
Gene Symbol: als2a
Previous Names: als2, si:dkey-33m14.1 (1)
Location: Chr: 9   Details
Nomenclature History
GENE EXPRESSION No data available
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 Genotypes

Allele Type Mutagen Suppliers
hu3525 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026736Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10766 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17354 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Phenotype of Human Orthologue OMIM Phenotype ID
    Amyotrophic lateral sclerosis 2, juvenile 205100
    Primary lateral sclerosis, juvenile 606353
    Spastic paralysis, infantile onset ascending 607225
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component axon (more)
    Molecular Function Rab GTPase binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000219 (1)
  • InterPro:IPR000408 (1)
  • InterPro:IPR003123 (1)
  • InterPro:IPR003409 (1)
  • InterPro:IPR009091 (1)
  • InterPro:IPR011993 (1)
  • PROSITE:PS00626 (1)
  • PROSITE:PS50010 (1)
  • PROSITE:PS50012 (1)
  • PROSITE:PS51205 (1)
  • Pfam:PF00415 (1)
  • Pfam:PF00621 (1)
  • Pfam:PF02204 (1)
  • Pfam:PF02493 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA als2a-001 (1) 2979
    als2a-002 (1) 1337
    als2a-003 (1) 377
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM als2a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    als2a Contained in: [BAC] DKEY-33M14 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_679972 (1) 5852 bp
    Genomic GenBank:BX571704 (1) 219065 bp Blast at MegaBLAST
    Polypeptide UniProtKB:I7L9G3 (1) 1590 aa
    Sequence Clusters UniGene:102729 (1)
    Sequence Information (all 18)
    OTHER als2a GENE PAGES
  • Gene:557014 (1)
  • VEGA:OTTDARG00000025589 (1)
  • Ensembl(Zv9):ENSDARG00000075111 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish als2a 9  
    Human ALS2 2 (2q33.1)
  • OMIM:606352
  • Gene:57679
  • Orthology Details
    CITATIONS (21)