ZFIN ID: ZDB-GENE-070402-2
Gene Name: alsin Rho guanine nucleotide exchange factor ALS2 a
Gene Symbol: als2a    Nomenclature History

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Previous Names: als2, si:dkey-33m14.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have Rab guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endosomal transport; glutamatergic synaptic transmission; and neuromuscular junction development. Predicted to localize to several cellular components, including centrosome; early endosome; and postsynaptic density. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2).
Genome Resources: Alliance (1),  Gene:557014 (1),  Ensembl(GRCz11):ENSDARG00000075111 (2)
GENE EXPRESSION No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH als2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 2 Alliance Amyotrophic lateral sclerosis 2, juvenile 205100
Primary lateral sclerosis, juvenile 606353
Spastic paralysis, infantile onset ascending 607225
DISEASE ASSOCIATED WITH als2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process axonogenesis (more)
Cellular Component axon (more)
Molecular Function Rab GTPase binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA als2a-202 (1)    Ensembl 1337
als2a-203 (1)    Ensembl 2979
als2a-204 (1)    Ensembl 377
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM als2a No data available
MARKER RELATIONSHIPS
als2a Contained in: [BAC] DKEY-33M14 (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_021478854 (1)
Genomic GenBank:BX571704 (1) 219065 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1QS60 (1) 1662 aa
Sequence Information (all 18)
ORTHOLOGY for als2a ( Chr: 9 )
CITATIONS (29)