ZFIN ID: ZDB-GENE-070228-3
Gene Name: hypocretin (orexin) receptor 2
Gene Symbol: hcrtr2    Nomenclature History

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Previous Names: hcrtr (2), hcrt receptor (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have orexin receptor activity and peptide binding activity. Involved in circadian behavior; melatonin metabolic process; and regulation of circadian sleep/wake cycle, sleep. Predicted to localize to integral component of plasma membrane. Is expressed in brain and spinal cord. Orthologous to human HCRTR2 (hypocretin receptor 2).
Genome Resources: Alliance (1),  Gene:561260 (1),  Ensembl(GRCz11):ENSDARG00000023722 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2098 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018425Tg Transgenic Insertion Unknown Unknown DNA
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH hcrtr2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hcrtr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process circadian behavior (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hcrtr2-201 (1)    Ensembl 1317
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hcrtr2 No data available
    MARKER RELATIONSHIPS
    hcrtr2 Contained in: [BAC] CH211-206N3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001079868 (1) 1275 nt
    Genomic GenBank:CT009597 (1) 138674 nt
    Select Tool
    Polypeptide UniProtKB:A1YQE3 (1) 424 aa
    Sequence Information (all 9)
    ORTHOLOGY for hcrtr2 ( Chr: 13 )
    CITATIONS (36)