ZFIN Gene: brd2b

ZFIN ID: ZDB-GENE-070220-1

ZFIN ID: ZDB-GENE-070220-1

Gene Name:

bromodomain containing 2b

Gene Symbol:

brd2b Nomenclature History

Previous Name:

Gene Type:

protein_coding_gene

Location:

Chr: 16 Mapping Details/Browsers

Description:

Involved in thrombocyte differentiation. Is expressed in several structures, including head; immature eye; nervous system; ovary; and swim bladder. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2).

Genome Resources:

Alliance (1), Gene:569354 (1), Ensembl(GRCz11):ENSDARG00000046087 (2)

GENE EXPRESSION
All Expression Data:	7 figures from Dibenedetto et al., 2008
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	brain cerebellum head heart hindbrain immature eye inner ear neural rod oocyte optic tectum optic vesicle otic placode ovary pectoral fin pharyngeal arch pharyngeal arch 3-7 skeleton pharynx swim bladder trunk whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa14579	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-brd2b	N/A	1
MO2-brd2b	N/A	1

PHENOTYPE

Data:	Fig. S22 from Bielczyk-Maczyńska et al., 2014
Observed in:	thrombocyte

DISEASE ASSOCIATED WITH brd2b HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH brd2b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	thrombocyte differentiation (more)

GO Terms (all 1)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	brd2b-202 (1)	4037	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	brd2b-203 (1)	1447	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM brd2b No data available

MARKER RELATIONSHIPS

brd2b Contained in:

[BAC] CH73-31D8 (1), CH73-376G11 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001110524 (1)	1467 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU694227 (1)	121472 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F8W3C9 (1)	811 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 18)

ORTHOLOGY for brd2b ( Chr: 16 )

CITATIONS (18)

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