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Gene

rps6ka3b

ID
ZDB-GENE-070209-74
Name
ribosomal protein S6 kinase, polypeptide 3b
Symbol
rps6ka3b Nomenclature History
Previous Names
  • zgc:158386
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable ribosomal protein S6 kinase activity. Acts upstream of or within ossification. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rps6ka3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Lowry syndrome Alliance Coffin-Lowry syndrome 303600
non-syndromic X-linked intellectual disability 19 Alliance Intellectual developmental disorder, X-linked 19 300844
Associated With rps6ka3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR017892 Protein kinase, C-terminal
Domain IPR041906 Ribosomal S6 kinase, N-terminal catalytic domain
Family IPR016239 Ribosomal protein S6 kinase II
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Protein kinase, ATP binding site Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Ribosomal protein S6 kinase II Ribosomal S6 kinase, N-terminal catalytic domain Serine/threonine-protein kinase, active site
UniProtKB:E9QIU5 692
UniProtKB:A0A2R8QG28 674
UniProtKB:F1R2A7 709
UniProtKB:A2RUY2 720
UniProtKB:A0A2R8QC98 689
UniProtKB:E7F469 722
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations