ZFIN ID: ZDB-GENE-070209-74
Gene Name: ribosomal protein S6 kinase, polypeptide 3b
Gene Symbol: rps6ka3b    Nomenclature History

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Previous Name: zgc:158386

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have ribosomal protein S6 kinase activity. Involved in ossification. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3).
Genome Resources: Alliance (1),  Gene:100009657 (1),  Ensembl(GRCz11):ENSDARG00000057927 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022934Tg Transgenic Insertion Unknown Unknown DNA
sa960 Point Mutation Unknown Premature Stop ENU
sa24507 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rps6ka3b N/A 1
    MO2-rps6ka3b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rps6ka3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Coffin-Lowry syndrome Alliance Coffin-Lowry syndrome 303600
    non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 19 300844
    DISEASE ASSOCIATED WITH rps6ka3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ossification (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rps6ka3b-201 (1)    Ensembl 3190
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rps6ka3b No data available
    MARKER RELATIONSHIPS
    rps6ka3b Contained in: [BAC] DKEY-226L10 (1) (order this)
    rps6ka3b Encodes: [cDNA] MGC:158386 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083026 (1) 3245 nt
    Genomic GenBank:BX248581 (1) 202872 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7F469 (1) 722 aa
    Sequence Information (all 21)
    ORTHOLOGY for rps6ka3b ( Chr: 24 )
    CITATIONS (23)