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ZIRC
ZFIN ID: ZDB-GENE-070209-23
Gene Name: drosha ribonuclease III
Gene Symbol: drosha    Nomenclature History

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Previous Names: drosha (1), im:7150667, rnasen, zgc:158612 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have double-stranded RNA binding activity and ribonuclease III activity. Involved in angiogenesis. Predicted to localize to the nucleus. Orthologous to human DROSHA (drosha ribonuclease III).
Genome Resources: Alliance (1), Gene:567505 (1), Ensembl(GRCz11):ENSDARG00000055563 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7150667]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018047Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa191 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13985 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17917 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31863 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35230 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sfc22 Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
    sfc23 Small Deletion Unknown Unknown CRISPR
    sfc25 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-drosha 1
    MO1-drosha N/A 1
    MO2-drosha N/A 1
    DISEASE ASSOCIATED WITH drosha HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH drosha VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process primary miRNA processing (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rnasen-201 (1)    Ensembl 4230
    ncRNA rnasen-002 (1)    Ensembl 711
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM droshaNo data available
    MARKER RELATIONSHIPS
    droshaContained in: [BAC] CH211-198P7 (1) (order this)
    droshaEncodes: [EST] IMAGE:7150667 (1) (order this)
    [cDNA] MGC:158612 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001110472 (1) 4157bp
    Genomic GenBank:BX571950 (1) 196442bp
    Select Tool
    Polypeptide UniProtKB:A2RV16 (1) 1289aa
    Sequence Clusters UniGene:132523 (1)
    Sequence Information (all 12)
    ORTHOLOGY for drosha (Chr: 12)
    CITATIONS (32)