ZFIN ID: ZDB-GENE-070209-131
Gene Name: transducin beta like 1 X-linked
Gene Symbol: tbl1x    Nomenclature History

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Previous Name: zgc:158242

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have transcription corepressor activity. Predicted to be involved in histone deacetylation and regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital nongoitrous hypothyroidism 8. Orthologous to human TBL1X (transducin beta like 1 X-linked) and TBL1Y (transducin beta like 1 Y-linked).
Genome Resources: Alliance (1),  Gene:560294 (1),  Ensembl(GRCz11):ENSDARG00000060438 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027093Tg Transgenic Insertion Unknown Unknown DNA
sa11514 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tbl1x HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital nongoitrous hypothyroidism 8 Alliance Hypothyroidism, congenital, nongoitrous, 8 301033
    Y-linked deafness 2 Alliance ?Deafness, Y-linked 2 400047
    DISEASE ASSOCIATED WITH tbl1x VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process histone deacetylation (more)
    Cellular Component histone deacetylase complex (more)
    Molecular Function transcription corepressor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbl1x-201 (1)    Ensembl 4177
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbl1x No data available
    MARKER RELATIONSHIPS
    tbl1x Contained in: [BAC] CH73-81E19 (1)
    tbl1x Encodes: [cDNA] MGC:158242 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001082994 (1) 4211 nt
    Genomic GenBank:CU469547 (1) 93540 nt
    Select Tool
    Polypeptide UniProtKB:A2RUX0 (1) 510 aa
    Sequence Information (all 8)
    ORTHOLOGY for tbl1x ( Chr: 9 )
    CITATIONS (20)