Gene

sos1

ID
ZDB-GENE-070209-128
Name
son of sevenless homolog 1 (Drosophila)
Symbol
sos1 Nomenclature History
Previous Names
  • fj59e07
  • wu:fj59e07 (1)
  • zgc:158274 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; guanyl-nucleotide exchange factor activity; and protein heterodimerization activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to localize to nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sos1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
gingival fibromatosis Alliance ?Fibromatosis, gingival, 1 135300
Noonan syndrome 4 Alliance Noonan syndrome 4 610733
Associated With sos1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019804 Ras guanine-nucleotide exchange factor, conserved site
Domain IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
Family IPR002119 Histone H2A
Family IPR008937 Ras-like guanine nucleotide exchange factor
Homologous_superfamily IPR009072 Histone-fold
Homologous_superfamily IPR023578 Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Domain Details Per Protein
Protein Length Histone-fold Histone H2A Ras guanine-nucleotide exchange factor, catalytic domain superfamily Ras guanine-nucleotide exchange factor, conserved site Ras guanine nucleotide exchange factor domain superfamily Ras guanine-nucleotide exchange factors catalytic domain Ras-like guanine nucleotide exchange factor
UniProtKB:A2RRV5 713
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations