Gene
nrxn3a
- ID
- ZDB-GENE-070206-9
- Name
- neurexin 3a
- Symbol
- nrxn3a Nomenclature History
- Previous Names
-
- nrxn3aa
- nrxn3ab
- im:7144250
- wu:fj54c11
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to act upstream of or within angiogenesis and cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in alcohol dependence and nicotine dependence. Orthologous to human NRXN3 (neurexin 3).
- Genome Resources
- Note
-
nrxn3a has two isoforms, alpha (2 forms DQ641432 and DQ641433) and beta (DQ641434)
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144250 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019947Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019948Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019949Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019950Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027815Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2921 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9245 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11330 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14031 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18056 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Domain | IPR027789 | Syndecan/Neurexin domain |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
nrxn3a-204
(1)
|
Ensembl | 2,987 nt | ||
| mRNA |
nrxn3a-201
(1)
|
Ensembl | 3,623 nt | ||
| mRNA |
nrxn3a-202
(1)
|
Ensembl | 2,099 nt | ||
| mRNA |
nrxn3a-203
(1)
|
Ensembl | 2,408 nt | ||
| mRNA |
nrxn3a-208
(1)
|
Ensembl | 4,008 nt | ||
| ncRNA |
nrxn3a-004
(1)
|
Ensembl | 788 nt | ||
| ncRNA |
nrxn3a-005
(1)
|
Ensembl | 776 nt | ||
| ncRNA |
nrxn3a-006
(1)
|
Ensembl | 437 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-154E6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-109B24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-153P6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-245F17 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-51D5 | ZFIN Curated Data | |
| Encodes | EST | fj54c11 | ||
| Encodes | EST | IMAGE:7144250 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:174586 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080009 (1) | 7351 nt | ||
| Genomic | GenBank:BX571723 (2) | 201159 nt | ||
| Polypeptide | UniProtKB:A1XQX8 (1) | 1697 aa |
- Jukic, A., Lei, Z., Cebul, E.R., Pinter, K., Tadesse, Y., Jarysta, A., David, S., Mosqueda, N., Tarchini, B., Kindt, K. (2024) Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells. Development (Cambridge, England). 151(19):
- Martin, A., Babbitt, A., Pickens, A.G., Pickett, B.E., Hill, J.T., Suli, A. (2022) Single-Cell RNA Sequencing Characterizes the Molecular Heterogeneity of the Larval Zebrafish Optic Tectum. Frontiers in molecular neuroscience. 15:818007
- Tromp, A., Robinson, K., Hall, T.E., Mowry, B., Giacomotto, J. (2021) Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions. G3 (Bethesda). 11(12):
- Koh, A., Tao, S., Jing, G.Y., Chaganty, V., See, K., Purushothaman, K., Orbán, L., Mathuru, A.S., Wohland, T., Winkler, C. (2020) A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish. Human molecular genetics. 29(23):3765-3780
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
- Maugars, G., Dufour, S., Cohen-Tannoudji, J., Quérat, B. (2014) Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution. PLoS One. 9:e111361
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