Gene
nrxn1b
- ID
- ZDB-GENE-070206-3
- Name
- neurexin 1b
- Symbol
- nrxn1b Nomenclature History
- Previous Names
-
- nrxn1ba
- nrxn1bb
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).
- Genome Resources
- Note
-
nrxn1b has two isoforms, alpha (DQ641426) and beta (DQ641427).
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nv1436 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa18533 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22192 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35390 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35391 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42109 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42110 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42111 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 8 of 8
Show
1 - 10 of 12
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pitt-Hopkins-like syndrome 2 | Alliance | Pitt-Hopkins-like syndrome 2 | 614325 |
| {Schizophrenia, susceptibility to, 17} | 614332 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Domain | IPR027789 | Syndecan/Neurexin domain |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin G domain | Neurexin-related cell adhesion and synaptic protein | Neurexin/syndecan/glycophorin C | Syndecan/Neurexin domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B4Y5
|
1440 | ||||||
|
UniProtKB:A1XQX3
|
448 | ||||||
|
UniProtKB:F1R7M4
|
448 | ||||||
|
UniProtKB:A0A8M3AYS8
|
1431 | ||||||
|
UniProtKB:A1XQX2
|
1470 | ||||||
|
UniProtKB:F8W597
|
1475 | ||||||
|
UniProtKB:A0A8M9PXV2
|
217 | ||||||
|
UniProtKB:A0A8M3B7R4
|
1457 | ||||||
|
UniProtKB:A0A8M3AYQ8
|
1466 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn1b-201
(1)
|
Ensembl | 7,191 nt | ||
| mRNA |
nrxn1b-202
(1)
|
Ensembl | 6,818 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-158E23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-58O21 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001290176 (1) | 8014 nt | ||
| Genomic | GenBank:AL929536 (1) | 151341 nt | ||
| Polypeptide | UniProtKB:F8W597 (1) | 1475 aa |
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Tromp, A., Robinson, K., Hall, T.E., Mowry, B., Giacomotto, J. (2021) Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions. G3 (Bethesda). 11(12):
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Maugars, G., Dufour, S. (2015) Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians. PLoS One. 10:e0135184
- Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
- Zheng, W., Li, Z., Nguyen, A.T., Li, C., Emelyanov, A., Gong, Z. (2014) Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One. 9:e91179
- Ehrmann, I., Dalgliesh, C., Liu, Y., Danilenko, M., Crosier, M., Overman, L., Arthur, H.M., Lindsay, S., Clowry, G.J., Venables, J.P., Fort, P., and Elliott, D.J. (2013) The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain. PLoS Genetics. 9(4):e1003474
- Rissone, A., Monopoli, M., Beltrame, M., Bussolino, F., Cotelli, F., and Arese, M. (2007) Comparative Genome Analysis of the Neurexin Gene Family in Danio rerio: Insights into Their Functions and Evolution. Mol. Biol. Evol.. 24(1):236-252
1 - 9 of 9
Show