ZFIN is now using GRCz12tu for Genomic Data
Gene
nrxn1a
- ID
- ZDB-GENE-070206-1
- Name
- neurexin 1a
- Symbol
- nrxn1a Nomenclature History
- Previous Names
-
- nrxn1aa
- nrxn1ab
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).
- Genome Resources
- Note
-
nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Rissone et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pitt-Hopkins-like syndrome 2 | Alliance | Pitt-Hopkins-like syndrome 2 | 614325 |
| {Schizophrenia, susceptibility to, 17} | 614332 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Domain | IPR027789 | Syndecan/Neurexin domain |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn1a-201
(1)
|
Ensembl | 1,425 nt | ||
| mRNA |
nrxn1a-202
(1)
|
Ensembl | 3,069 nt | ||
| mRNA |
nrxn1a-203
(1)
|
Ensembl | 9,670 nt | ||
| mRNA |
nrxn1a-204
(1)
|
Ensembl | 7,007 nt | ||
| mRNA |
nrxn1a-205
(1)
|
Ensembl | 6,457 nt | ||
| mRNA |
nrxn1a-207
(1)
|
Ensembl | 9,643 nt | ||
| mRNA |
nrxn1a-208
(1)
|
Ensembl | 9,682 nt | ||
| mRNA |
nrxn1a-209
(1)
|
Ensembl | 9,649 nt | ||
| ncRNA |
nrxn1a-004
(1)
|
Ensembl | 906 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers