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Gene

nrxn1a

ID
ZDB-GENE-070206-1
Name
neurexin 1a
Symbol
nrxn1a Nomenclature History
Previous Names
  • nrxn1aa
  • nrxn1ab
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable metal ion binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).
Genome Resources
Note
nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Rissone et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nrxn1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pitt-Hopkins-like syndrome 2 Alliance Pitt-Hopkins-like syndrome 2 614325
{Schizophrenia, susceptibility to, 17} 614332
Associated With nrxn1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR003585 Neurexin/syndecan/glycophorin C
Domain IPR027789 Syndecan/Neurexin domain
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like domain Laminin G domain Neurexin/syndecan/glycophorin C Syndecan/Neurexin domain
UniProtKB:A1XQX1 449
UniProtKB:A1XQX0 1491
UniProtKB:A0A2R8RRB9 1470
UniProtKB:A0A2R8QMY4 1188
UniProtKB:A0A2R8QIT7 1468
UniProtKB:A0A2R8QKE7 1481
UniProtKB:B6EUL5 419
UniProtKB:A5PL42 298
UniProtKB:A0A140TAU1 1484
UniProtKB:E7F420 1477
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations