ZFIN ID: ZDB-GENE-070206-1
Gene Name: neurexin 1a
Gene Symbol: nrxn1a    Nomenclature History

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Previous Names: nrxn1aa, nrxn1ab

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity. Involved in sprouting angiogenesis. Predicted to localize to integral component of membrane. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).
Genome Resources: Alliance (1),  Gene:565531 (1),  Ensembl(GRCz11):ENSDARG00000061647 (1)
Note: nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018138Tg Transgenic Insertion Unknown Unknown DNA
sa641 Point Mutation Unknown Premature Stop ENU
sa4466 Point Mutation Unknown Splice Site ENU
sa15915 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35299 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nrxn1a
    2
    CRISPR2-nrxn1a
    2
    MO1-nrxn1a N/A 1
    MO2-nrxn1a N/A 1
    MO3-nrxn1a N/A 1
    DISEASE ASSOCIATED WITH nrxn1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Pitt-Hopkins-like syndrome 2 Alliance Pitt-Hopkins-like syndrome 2 614325
    {Schizophrenia, susceptibility to, 17} 614332
    DISEASE ASSOCIATED WITH nrxn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nrxn1a-201 (1)    Ensembl 1425
    nrxn1a-202 (1)    Ensembl 3069
    nrxn1a-204 (1)    Ensembl 7007
    ncRNA nrxn1a-004 (1) 906
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nrxn1a No data available
    MARKER RELATIONSHIPS
    nrxn1a Contained in: [BAC] CH211-10G22 (1), DKEY-4P13 (1) (order this), DKEY-186O1 (1) (order this), DKEY-220B14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080021 (1) 6406 nt
    Genomic RefSeq:NW_018394843 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A1XQX0 (1) 1491 aa
    Sequence Information (all 91)
    ORTHOLOGY for nrxn1a ( Chr: 12 )
    CITATIONS (29)