ZFIN ID: ZDB-GENE-070202-9
Gene Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
Gene Symbol: kcnma1a    Nomenclature History

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Previous Names: kcnma1, slo1a (1), si:ch211-39f22.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have large conductance calcium-activated potassium channel activity. Involved in response to auditory stimulus. Predicted to localize to postsynaptic membrane. Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
Genome Resources: Alliance (1),  Gene:568554 (1),  Ensembl(GRCz11):ENSDARG00000079840 (2)
GENE EXPRESSION
All Expression Data: Fig. TS3 from Gabashvili et al., 2007
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
DISEASE ASSOCIATED WITH kcnma1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cerebellar atrophy, developmental delay, and seizures 617643
Liang-Wang syndrome 618729
Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy 609446
{Epilepsy, idiopathic generalized, susceptibility to, 16} 618596
DISEASE ASSOCIATED WITH kcnma1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to auditory stimulus (more)
Cellular Component integral component of membrane (more)
Molecular Function ion channel activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA kcnma1a-205 (1)    Ensembl 3823
ncRNA kcnma1a-002 (1)    Ensembl 849
kcnma1a-003 (1)    Ensembl 725
kcnma1a-004 (1)    Ensembl 857
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kcnma1a No data available
MARKER RELATIONSHIPS
kcnma1a Contained in: [BAC] CH211-39F22 (1), CH211-140C17 (1), CH211-215D15 (1), RP71-1G24 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001145600 (1)
Genomic GenBank:AL954192 (1) 198052 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QRZ7 (1) 1229 aa
Sequence Information (all 89)
ORTHOLOGY for kcnma1a ( Chr: 13 )
CITATIONS (22)