ZFIN Gene: celsr3

ZFIN ID: ZDB-GENE-070122-3

ZFIN ID: ZDB-GENE-070122-3

Gene Name:

cadherin, EGF LAG seven-pass G-type receptor 3

Gene Symbol:

celsr3 Nomenclature History

Previous Name:

Gene Type:

protein_coding_gene

Location:

Chr: 8 Mapping Details/Browsers

Description:

Predicted to have G protein-coupled receptor activity and calcium ion binding activity. Involved in gamma-aminobutyric acid signaling pathway. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in brain; eye; and muscle. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3).

Genome Resources:

Alliance (1), Gene:100008568 (1), Ensembl(GRCz11):ENSDARG00000055825 (2)

GENE EXPRESSION
All Expression Data:	3 figures from 3 publications
Wild-type Stages, Structures:	Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
	amacrine cell brain eye muscle retinal bipolar neuron retinal ganglion cell retinal ganglion cell layer whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
celsr3_unrecovered	Point Mutation	Unknown	Unknown	ENU
fh339	Point Mutation	Unknown	Unknown	ENU	China Zebrafish Resource Center (CZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa2445	Point Mutation	Unknown	Premature Stop	ENU
sa7333	Point Mutation	Unknown	Splice Site	ENU
sa9305	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa10576	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa11108	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa21306	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34415	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34416	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34417	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38693	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38694	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
w65	Point Mutation	Exon 1	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-celsr3	N/A	1
MO2-celsr3	N/A	1

PHENOTYPE

Data:	4 figures from Lewis et al., 2011
Observed in:	cellular response to light stimulus eye ON-bipolar cell axon terminus ON-bipolar cell optomotor response response to light stimulus swim bladder whole organism

DISEASE ASSOCIATED WITH celsr3 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH celsr3 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	gamma-aminobutyric acid signaling pathway (more)
Cellular Component	integral component of membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	celsr3-202 (1)	1323	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	celsr3-203 (1)	1219	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	celsr3-204 (1)	6195	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM celsr3 No data available

MARKER RELATIONSHIPS

celsr3 Contained in:

[BAC] CH211-122M4 (1), DKEY-20D21 (1) (order this), DKEY-90L2 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_009304014 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CR847503 (1)	217514 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:A9C3S7 (1)	2065 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 20)

ORTHOLOGY for celsr3 ( Chr: 8 )

CITATIONS (26)

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