ZFIN ID: ZDB-GENE-070117-2515
Gene Name: neuronal PAS domain protein 4 like
Gene Symbol: npas4l    Nomenclature History

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Previous Names: clo (1), cloche (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity. Involved in several processes, including circulatory system development; hemopoiesis; and negative regulation of cardioblast differentiation. Predicted to localize to the nucleus. Is expressed in anterior lateral plate mesoderm; posterior lateral mesoderm; posterior lateral plate mesoderm; and tail bud.
Genome Resources: Alliance (1),  Gene:108449885 (1),  Ensembl(GRCz11):ENSDARG00000116511 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns59 Small Deletion Unknown Frameshift, Premature Stop CRISPR
bns297 Small Deletion Exon 2 Premature Stop CRISPR
fv087b Unknown Unknown Unknown ENU
la1164 Unknown Unknown Unknown
m39 Deficiency Unknown Unknown SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m378 Unknown Unknown Unknown ENU
    npas4l_unspecified Unspecified Unknown Unknown
    s5 Point Mutation Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sk4 Unknown Unknown Unknown SPONTANEOUS
    sm0 Point Mutation Unknown Unknown ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • t22499 Point Mutation Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-npas4l 1
    CRISPR2-npas4l
    1
    CRISPR3-npas4l
    1
    CRISPR4-npas4l
    1
    CRISPR5-npas4l
    1
    CRISPR6-npas4l 1
    MO1-npas4l N/A 2
    MO2-npas4l N/A 2
    DISEASE ASSOCIATED WITH npas4l HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH npas4l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myeloid cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000014 PAS domain
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Homologous_superfamily IPR035965 PAS domain superfamily
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM npas4l
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(hsp70l:loxp-stop-loxp-npas4l-2a-mcherry) hsp70l 2ALOXPmCherrynpas4l Danio rerio 1 1
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001329912 (1)
    Genomic GenBank:CABZ01080135 (1)
    Polypeptide UniProtKB:A0A2R8QFU7 (1) 658 aa
    Sequence Information (all 13)
    ORTHOLOGY for npas4l ( Chr: 13 )
    CITATIONS (186)