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ZIRC
ZFIN ID: ZDB-GENE-070117-2205
Gene Name: dynactin 1a
Gene Symbol: dctn1a    Nomenclature History

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Previous Names: dnct1 (1), bug, mikre oko, mok

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in several processes, including apical protein localization; nuclear migration; and retina morphogenesis in camera-type eye. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is expressed in head; nervous system; and presumptive neural retina. Orthologous to human DCTN1 (dynactin subunit 1).
Genome Resources: Alliance (1),  Gene:407638 (1),  Ensembl(GRCz11):ENSDARG00000019743 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m632 Point Mutation Unknown Premature Stop ENU
s309 Point Mutation Unknown Premature Stop ENU
sa14467 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40818 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dctn1a N/A 1
    MO2-dctn1a N/A 2
    DISEASE ASSOCIATED WITH dctn1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 1 Alliance {Amyotrophic lateral sclerosis, susceptibility to} 105400
    distal hereditary motor neuronopathy type 7B Alliance Neuropathy, distal hereditary motor, type VIIB 607641
    Perry syndrome Alliance Perry syndrome 168605
    DISEASE ASSOCIATED WITH dctn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process camera-type eye photoreceptor cell differentiation (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dctn1a-201 (1)    Ensembl 8004
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dctn1a No data available
    MARKER RELATIONSHIPS
    dctn1a Contained in: [BAC] DKEY-31G16 (1) (order this), DKEY-162H11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077212 (1) 3825 bp
    Genomic GenBank:CT030017 (1) 222916 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8RP20 (1) 1257 aa
    Sequence Clusters UniGene:77671 (1)
    Sequence Information (all 17)
    ORTHOLOGY for dctn1a ( Chr: 7 )
    CITATIONS (30)