Gene

dctn1a

ID
ZDB-GENE-070117-2205
Name
dynactin 1a
Symbol
dctn1a Nomenclature History
Previous Names
  • dnct1 (1)
  • bug
  • mikre oko
  • mok
  • p150a (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have microtubule plus-end binding activity. Involved in several processes, including apical protein localization; nuclear migration; and retina morphogenesis in camera-type eye. Predicted to localize to several cellular components, including axon; kinetochore; and microtubule cytoskeleton. Is expressed in head; muscle; nervous system; presumptive neural retina; and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dctn1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 1 Alliance {Amyotrophic lateral sclerosis, susceptibility to} 105400
distal hereditary motor neuronopathy type 7B Alliance Neuronopathy, distal hereditary motor, type VIIB 607641
Perry syndrome Alliance Perry syndrome 168605
Associated With dctn1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000938 CAP Gly-rich domain
Domain IPR022157 Dynein associated protein
Homologous_superfamily IPR036859 CAP Gly-rich domain superfamily
Domain Details Per Protein
Protein Length CAP Gly-rich domain CAP Gly-rich domain superfamily Dynein associated protein
UniProtKB:F1R0W9 1218
UniProtKB:A0A286YA27 1250
UniProtKB:A0A2R8RP20 1257
UniProtKB:Q07DR3 1218
UniProtKB:Q7T2F8 910
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations