ZFIN ID: ZDB-GENE-070117-2
Gene Name: dystrobrevin, alpha
Gene Symbol: dtna    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have zinc ion binding activity. Predicted to be involved in synaptic signaling. Predicted to localize to plasma membrane and synapse. Is expressed in brain; notochord; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha).
Genome Resources: Alliance (1),  Gene:794932 (1),  Ensembl(GRCz11):ENSDARG00000031015 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa670 Point Mutation Unknown Premature Stop ENU
sa19346 Point Mutation Unknown Splice Site ENU
sa31102 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37939 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37940 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44175 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dtna HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    left ventricular noncompaction Alliance Left ventricular noncompaction 1, with or without congenital heart defects 604169
    DISEASE ASSOCIATED WITH dtna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process synaptic signaling (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dtna-201 (1)    Ensembl 2342
    dtna-202 (1)    Ensembl 2415
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dtna No data available
    MARKER RELATIONSHIPS
    dtna Contained in: [BAC] CH211-176D9 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080581 (1) 2354 nt
    Genomic GenBank:BX005079 (1) 157845 nt
    Select Tool
    Polypeptide UniProtKB:A2CJ03 (1) 714 aa
    Sequence Information (all 32)
    ORTHOLOGY for dtna ( Chr: 24 )
    CITATIONS (19)