Gene

ptgis

ID
ZDB-GENE-070116-1
Name
prostaglandin I2 (prostacyclin) synthase
Symbol
ptgis Nomenclature History
Previous Names
  • ptgisl
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Exhibits heme binding activity and prostaglandin-I synthase activity. Involved in prostaglandin biosynthetic process. Predicted to localize to endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Yeh et al., 2006
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptgis Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential hypertension Alliance Hypertension, essential 145500
Associated With ptgis Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001128 Cytochrome P450
Family IPR002403 Cytochrome P450, E-class, group IV
Family IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
Family IPR027286 Prostacyclin synthase
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type Cytochrome P450, E-class, group IV Cytochrome P450 superfamily Prostacyclin synthase
UniProtKB:F1RE08 480
UniProtKB:Q08C16 404
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations