Community Action Needed: Please respond to the NIH RFI
Gene

ogg1

ID
ZDB-GENE-070112-932
Name
8-oxoguanine DNA glycosylase
Symbol
ogg1 Nomenclature History
Previous Names
  • zgc:158858
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity. Acts upstream of or within animal organ development; negative regulation of neuron apoptotic process; and regulation of neuron projection development. Predicted to be active in nucleus. Is expressed in several structures, including anterior lateral plate mesoderm; anterior presumptive neural plate; nervous system; pericardial region; and pronephric duct. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ogg1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nonpapillary renal cell carcinoma Alliance Renal cell carcinoma, clear cell, somatic 144700
Associated With ogg1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003265 HhH-GPD domain
Domain IPR012904 8-oxoguanine DNA glycosylase, N-terminal
Homologous_superfamily IPR011257 DNA glycosylase
Homologous_superfamily IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal
Domain Details Per Protein
Protein Length 8-oxoguanine DNA glycosylase, N-terminal DNA glycosylase Helix-turn-helix, base-excision DNA repair, C-terminal HhH-GPD domain
UniProtKB:A1L2F5 268
UniProtKB:Q0P4B1 388
UniProtKB:B0UYD9 317
UniProtKB:B0R135 391
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations