Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-070112-482
Gene Name: D-2-hydroxyglutarate dehydrogenase
Gene Symbol: d2hgdh
Previous Name: zgc:158661
Nomenclature History
GENE EXPRESSION
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa16838, sa17480
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
D-2-hydroxyglutaric aciduria 600721
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component mitochondrion (more)
Molecular Function UDP-N-acetylmuramate dehydrogenase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004113 (1)
  • InterPro:IPR006094 (1)
  • InterPro:IPR016164 (1)
  • InterPro:IPR016166 (1)
  • InterPro:IPR016167 (1)
  • InterPro:IPR016169 (1)
  • InterPro:IPR016171 (1)
  • PROSITE:PS51387 (1)
  • Pfam:PF01565 (1)
  • Pfam:PF02913 (1)
  • EC:1.1.99.- (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA d2hgdh-001 (1) 1833
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM d2hgdh No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    d2hgdh Contained in: [BAC] CH211-62C1 (1) (order this)
    d2hgdh Encodes: [cDNA] MGC:158661 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001080597 (1) 1836 bp
    Genomic RefSeq:NW_003039255 (1) 207830 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A1L258 (1) 533 aa
    Sequence Clusters UniGene:86117 (1)
    Sequence Information (all 14)
    OTHER d2hgdh GENE PAGES
  • Gene:565889 (1)
  • VEGA:OTTDARG00000025849 (1)
  • Ensembl(Zv9):ENSDARG00000060210 (1)
  • MAPPING INFORMATION
    Chr: 2 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA
    Zebrafish d2hgdh 2  
    Human D2HGDH 2 (2q37.3)
  • OMIM:609186
  • Gene:728294
  • Mouse D2hgdh 1 ( 47.36 cM)
  • MGI:2138209
  • Gene:98314
  • CITATIONS (14)