ZFIN ID: ZDB-GENE-070112-342
Gene Name: guanine nucleotide binding protein (G protein), beta 5a
Gene Symbol: gnb5a    Nomenclature History

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Previous Name: zgc:158678

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to contribute to GTPase activator activity. Involved in heart contraction; optokinetic behavior; and swimming behavior. Predicted to localize to cytoplasm and heterotrimeric G-protein complex. Orthologous to human GNB5 (G protein subunit beta 5).
Genome Resources: Alliance (1),  Gene:562813 (1),  Ensembl(GRCz11):ENSDARG00000099685 (1)
GENE EXPRESSION
All Expression Data: Fig. S1 from Xu et al., 2012
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu11433 Insertion Unknown Premature Stop CRISPR
sa25222 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-gnb5a 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gnb5a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with cardiac arrhythmia 617173
Language delay and ADHD/cognitive impairment with or without cardiac arrhythmia 617182
DISEASE ASSOCIATED WITH gnb5a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component membrane (more)
Molecular Function G-protein gamma-subunit binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gnb5a-202 (1)    Ensembl 1413
ncRNA gnb5a-002 (1)    Ensembl 447
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gnb5a No data available
MARKER RELATIONSHIPS
gnb5a Contained in: [BAC] CH211-286K11 (1)
gnb5a Encodes: [cDNA] MGC:158678 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001080181 (1) 1428 nt
Genomic GenBank:AL954697 (1) 134798 nt
Select Tool
Polypeptide UniProtKB:A1L271 (1) 355 aa
Sequence Information (all 9)
ORTHOLOGY for gnb5a ( Chr: 25 )
CITATIONS (22)