Gene

glis3

ID
ZDB-GENE-070112-2232
Name
GLIS family zinc finger 3
Symbol
glis3 Nomenclature History
Previous Names
  • wu:fa55a05
  • zgc:158249 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to nucleus. Is expressed in several structures, including brain; otic vesicle; pectoral fin bud; pharyngeal endoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glis3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neonatal diabetes mellitus with congenital hypothyroidism Alliance Diabetes mellitus, neonatal, with congenital hypothyroidism 610199
Associated With glis3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Family IPR043359 C2H2-type zinc-finger protein GLI-like
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length C2H2-type zinc-finger protein GLI-like Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A1L1Q6 787
UniProtKB:F1QB13 803
UniProtKB:A0A0R4IU95 787
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations