Gene

kdm6al

ID
ZDB-GENE-070112-2002
Name
lysine (K)-specific demethylase 6A, like
Symbol
kdm6al Nomenclature History
Previous Names
  • utx1 (1)
  • utxl1
  • uty (1)
  • zgc:158313 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone demethylase activity (H3-K27 specific). Involved in animal organ development; anterior/posterior pattern specification; and germ cell migration. Predicted to localize to MLL3/4 complex and nuclear chromatin. Human ortholog(s) of this gene implicated in Kabuki syndrome; acute lymphoblastic leukemia; and esophagus squamous cell carcinoma. Is expressed in blood island. Orthologous to human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kdm6al Human Ortholog
No data available
Associated With kdm6al Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003347 JmjC domain
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Repeat IPR019734 Tetratricopeptide repeat
Domain Details Per Protein
Protein Length JmjC domain Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat
UniProtKB:X1WDW1 303
UniProtKB:A1L1S9 1311
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations