ZFIN ID: ZDB-GENE-070112-2002
Gene Name: lysine (K)-specific demethylase 6A, like
Gene Symbol: kdm6al    Nomenclature History

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Previous Names: utx1 (1), utxl1, uty (1), zgc:158313 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone demethylase activity (H3-K27 specific). Involved in animal organ development; anterior/posterior pattern specification; and germ cell migration. Predicted to localize to MLL3/4 complex and nuclear chromatin. Is expressed in blood island. Human ortholog(s) of this gene implicated in Kabuki syndrome; acute lymphoblastic leukemia; and esophagus squamous cell carcinoma. Orthologous to human KDM6A (lysine demethylase 6A) and UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked).
Genome Resources: Alliance (1),  Gene:569207 (1),  Ensembl(GRCz11):ENSDARG00000059794 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Pharyngula:Prim-15 (30.0h-36.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029267Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdm6al
    4
    CRISPR2-kdm6al
    1
    MO1-kdm6al N/A 3
    MO2-kdm6al N/A 3
    MO3-kdm6al N/A 1
    DISEASE ASSOCIATED WITH kdm6al HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH kdm6al VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component MLL3/4 complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript kdm6al-203 (1)    Ensembl 5865
    mRNA kdm6al-201 (1)    Ensembl 4921
    ncRNA kdm6al-003 (1)    Ensembl 208
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm6al No data available
    MARKER RELATIONSHIPS
    kdm6al Contained in: [Fosmid] CH1073-158D14 (1), CH1073-389C18 (1), CH1073-441H10 (1)
    kdm6al Encodes: [cDNA] MGC:158313 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080193 (1) 4954 nt
    Genomic GenBank:CU855795 (1) 37498 nt
    Select Tool
    Polypeptide UniProtKB:A1L1S9 (1) 1311 aa
    Sequence Information (all 17)
    ORTHOLOGY for kdm6al ( Chr: 6 )
    CITATIONS (30)