Gene
aqp8a.2
- ID
- ZDB-GENE-070112-1802
- Name
- aquaporin 8a, tandem duplicate 2
- Symbol
- aqp8a.2 Nomenclature History
- Previous Names
-
- aqp8ab (1)
- zgc:158752
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables urea transmembrane transporter activity and water transmembrane transporter activity. Acts upstream of or within digestive tract development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine and kidney. Orthologous to human AQP8 (aquaporin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12944 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15808 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3698 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| zf3699 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| zf3700 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aquaporin 8 | Aquaporin-like | Aquaporin transporter | Major intrinsic protein |
|---|---|---|---|---|---|---|
| UniProtKB:A1L2B1 | InterPro | 257 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aqp8a.2-201
(1)
|
Ensembl | 1,148 nt | ||
| mRNA |
aqp8a.2-202
(1)
|
Ensembl | 1,872 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218L14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-69N5 | ||
| Encodes | cDNA | MGC:158752 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192596 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080182 (1) | 1169 nt | ||
| Genomic | GenBank:CR352324 (1) | 206894 nt | ||
| Polypeptide | UniProtKB:A1L2B1 (1) | 257 aa |
- Wang, S., Qin, Y., Sheng, J., Duan, X., Shen, L., Liu, D. (2022) Aquaporin 8ab is required in zebrafish embryonic intestine development. Acta biochimica et biophysica Sinica. 54:1-9
- Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron, V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978
- Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron,V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978
- Dong, C., Chen, L., Feng, J., Xu, J., Mahboob, S., Al-Ghanim, K., Li, X., Xu, P. (2016) Genome Wide Identification, Phylogeny, and Expression of Aquaporin Genes in Common Carp (Cyprinus carpio). PLoS One. 11:e0166160
- Koun, S., Kim, J.D., Rhee, M., Kim, M.J., Huh, T.L. (2016) Spatiotemporal expression pattern of the zebrafish aquaporin 8 family during early developmental stages. Gene expression patterns : GEP. 21(1):1-6
- Cazaméa-Catalan, D., Besseau, L., Falcón, J., Magnanou, E. (2014) The Timing of Timezyme Diversification in Vertebrates. PLoS One. 9:e112380
- Tingaud-Sequeira, A., Calusinska, M., Finn, R.N., Chauvigne, F., Lozano, J., and Cerda, J. (2010) The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals. BMC Evolutionary Biology. 10:38
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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