ZFIN ID: ZDB-GENE-070112-172
Gene Name: galactose-1-phosphate uridylyltransferase
Gene Symbol: galt    Nomenclature History

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Previous Name: zgc:158795 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in galactose catabolic process via UDP-galactose. Predicted to localize to the cytoplasm. Used to study galactosemia. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase).
Genome Resources: Alliance (1),  Gene:791130 (1),  Ensembl(GRCz11):ENSDARG00000069543 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027140Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21683 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2028 Small Deletion Unknown Unknown TALEN
    zf2029 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-galt 1
    DISEASE ASSOCIATED WITH galt HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    classic galactosemia Alliance Galactosemia 230400
    DISEASE ASSOCIATED WITH galt VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    galactosemia galtzf2028/zf2028 standard conditions Vanoevelen et al., 2017
    galtzf2029/zf2029 standard conditions Vanoevelen et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process galactose catabolic process via UDP-galactose (more)
    Cellular Component cytoplasm (more)
    Molecular Function UDP-glucose:hexose-1-phosphate uridylyltransferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR019779 Galactose-1-phosphate uridyl transferase, class I His-active site
    Domain IPR005849 Galactose-1-phosphate uridyl transferase, N-terminal
    Domain IPR005850 Galactose-1-phosphate uridyl transferase, C-terminal
    Family IPR001937 Galactose-1-phosphate uridyl transferase, class I
    Homologous_superfamily IPR036265 HIT-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA galt-201 (1)    Ensembl 1417
    galt-203 (1)    Ensembl 1857
    ncRNA galt-002 (1) 806
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM galt No data available
    MARKER RELATIONSHIPS
    galt Contained in: [BAC] CH211-234J17 (1), CH211-262G12 (1)
    galt Encodes: [cDNA] MGC:158795 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080612 (1) 1263 nt
    Genomic GenBank:BX927402 (1) 155963 nt
    Select Tool
    Polypeptide UniProtKB:E9QE09 (1) 364 aa
    Sequence Information (all 19)
    ORTHOLOGY for galt ( Chr: 10 )
    CITATIONS (22)