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ZIRC
ZFIN ID: ZDB-GENE-070108-1
Gene Name: sestrin 2
Gene Symbol: sesn2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including cellular response to leucine; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to colocalize with the GATOR2 complex; TORC2 complex; and cytoplasm. Orthologous to human SESN2 (sestrin 2).
Genome Resources: Alliance (1),  Gene:100149745 (1),  Ensembl(GRCz11):ENSDARG00000070012 (2)
GENE EXPRESSION
All Expression Data: Table 1 from Scheldeman et al., 2017
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sesn2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH sesn2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of response to reactive oxygen species (more)
Cellular Component nucleus (more)
Molecular Function leucine binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006730 (1)
  • InterPro:IPR029032 (1)
  • Pfam:PF04636 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sesn2-201 (1)    Ensembl 1931
    sesn2-202 (1)    Ensembl 836
    sesn2-203 (1)    Ensembl 877
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sesn2 No data available
    MARKER RELATIONSHIPS
    sesn2 Contained in: [BAC] CH211-181O15 (1) (order this)
    sesn2 Encodes: [cDNA] MGC:162974 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001079975 (1) 1980 bp
    Genomic GenBank:CU104776 (1) 106546 bp
    Select Tool
    Polypeptide UniProtKB:A0F081 (1) 444 aa
    Sequence Clusters UniGene:44360 (1)
    Sequence Information (all 20)
    ORTHOLOGY for sesn2 ( Chr: 19 )
    CITATIONS (18)